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Symposium OO: Materials and Strategies for Lab-on-a-Chip -- Biological Analysis, Cell-Material Interfaces, and Fluidic Assembly of Nanostructures

Symposium OO: Materials and Strategies for Lab-on-a-Chip -- Biological Analysis, Cell-Material Interfaces, and Fluidic Assembly of Nanostructures Image
Materials and Strategies for Lab-on-a-Chip--Biological Analysis, Cell-Material Interfaces, and Fluidic Assembly of Nanostructures
April 14 - 17, 2009
Chairs
Shashi Murthy     Northeastern University
Henry Zeringue     University of Pittsburgh
Saif Khan     National University of Singapore
Victor Ugaz     Texas A&M University

Symposium Support
Dept of Chemical Engineering, Northeastern University
Microfluidic ChipShop GmbH


* Invited paper

SESSION OO1: Frontiers in Lab-on-a-Chip Research I
Chair: Shashi Murthy
Tuesday Morning, April 14, 2009
Room 3016 (Moscone West)

8:00 AM *OO1.1
Precision Measurement in Biology. Stephen Quake, Bioengineering and Applied Physics, Stanford University and Howard Hughes Medical Institute, Stanford, California.

8:30 AM *OO1.2
Nanoplasmonics and Integrated Biological Microprocessor for Molecular Medicine. Luke P. Lee, Department of Bioengineering, University of California, Berkeley, Berkeley, California; Berkeley Sensor and Actuator Center, University of California, Berkeley, Berkeley, California; Biomolecular Nanotechnology Center, University of California, Berkeley, Berkeley, California.

9:00 AM *OO1.3
Polymer-based Micro- and Nanofluidic Chips: Simple Strategies for Their Surface Modifications to Accommodate Applications in Biology. Steven Soper1,3, Robin L McCarley1,3, Michael C Murphy3,2, Sunggook Park3,2 and Dimitris E Nikitopoulos3,2; 1Chemistry, Louisiana State University, Baton Rouge, Louisiana; 2Center for BioModular Multi-Scale Systems, Louisiana State University, Baton Rouge, Louisiana; 3Department of Mechanical Engineering, Louisiana State University, Baton Rouge, Louisiana.

9:30 AM *OO1.4
Molecular Gates for Attoliter Manipulation, Analysis, and Deposition of Biofluidic Compounds. Mark A. Shannon, Mechanical Science and Engineering, University of Illinois, Urbana, Illinois; Beckman Institute, University of Illinois, Urbana, Illinois.

10:00 AM BREAK

10:30 AM *OO1.5
Microfluidics and nanofluidics for Labs-on-a-Chip. Albert van den Berg, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, Enschede, Netherlands.

11:00 AM *OO1.6
Droplets & Microfluidics: Novel Tools in Nanomaterial Synthesis. Andrew J. deMello, Department of Chemistry, Imperial College London, South Kensington, United Kingdom.

11:30 AM *OO1.7
Stop Flow Lithography to Create Functional Microparticles. Patrick Doyle, Chemical Engineering, MIT, Cambridge, Massachusetts.

SESSION OO2: Frontiers in Lab-on-a-Chip Research II
Chair: Shashi Murthy
Tuesday Afternoon, April 14, 2009
Room 3016 (Moscone West)

1:30 PM *OO2.1
Microfluidic Manifolds with High Dynamic Range in Structural Dimensions Replicated in Thermoplastic Materials. Holger Becker1, Erik Beckert2 and Claudia Gaertner1; 1Microfluidic ChipShop GmbH, Jena, Germany; 2Fraunhofer Institute for Applied Optics and Precision Engineering, Jena, Germany.

2:00 PM *OO2.2
Tetherless, 3D, Micro-Nanoscale Tools and Devices for Lab on a Chip Applications. David Gracias, Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland; Chemistry, Johns Hopkins University, Baltimore, Maryland; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, Maryland.

2:30 PM *OO2.3
An Investigation into the “World-to-chip” Interface. Sammy S. Datwani, Labcyte, Inc., Sunnyvale, California.

SESSION OO3: Poster Session: Materials for Lab-on-a-Chip
Chair: Xuanhong Cheng
Tuesday Evening, April 14, 2009
5 :00 PM
Exhibit Hall (Moscone West)

OO3.1
Hot Embossing Of Microchannels in Cyclic Olefin Copolymers. Patrick W. Leech, CSIRO, Materials Science and Engineering, Clayton, Victoria, Australia.

OO3.2
A Vacuum Manifold to Rapidly Connect Fluid Inlets and Pneumatic Lines to PDMS Microdevices. Gregory Alan Cooksey, Anne L Plant and Javier Atencia; Biochemical Sciences Division, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland.

OO3.3
MALDI-TOF MS as a New Bio-analytical Tool : Application to Ultrasensitive Antigen Detection and Absolute Quantification of Proteins on Biochips. Juhee Lee1, Jung Rok Lee2, Kwang Pyo Kim2, Sul-Jin Kwack3, Dal-Hee Min3, Hyung Soon Park4 and Woon-Seok Yeo1; 1Bioscience and Biotechnalogy, konkuk University, Seoul, Korea, South; 2Molecular Biotechnology, Konkuk University, Seoul, Korea, South; 3Chemistry, KAIST, Seoul, Korea, South; 4Probiond Co., Ltd., Seoul, Korea, South.

OO3.4
Controlled Fabrication of Line Patterns using Microfluidic Photomasks Jae-Hoon Choi1,2, Seung-Kon Lee1,2, Shin-Hyun Kim1,2, Sung-Gyu Park1,2, Jun-Hyuk Moon3 and Seung-Man Yang1,2; 1Chemical and Biomolecular Eng., KAIST, DaeJeon, Korea, South; 2National Creative Research Initiative Center for Integrated Optofluidic Systems, KAIST, Daejeon, Korea, South; 3Chemical and Biomolecular Eng., Sogang University, Seoul, Korea, South.

OO3.5
Colloidosomes: ``Smart" Materials for Biomedical Applications. Rachel Rosenberg, Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania.

OO3.6
Electrochemical Detachment of a Novel Bioactive Hydrogel from Optically Transparent Microelectrodes Mihye Kim1, Sunny Shah2, Ji Youn Lee2, Alexander Revzin2 and Giyoong Tae1; 1Materials of science and engineering, Gwangju institute of science and technology, Gwangju, Korea, South; 2Department of Biomedical Engineering, University of California, Davis, California.

OO3.7
Dynamic Bio-Nano System on a CMOS Microarray by Magnetic Electric Patterning. Zhen Gu2,3, Lei Zhang1,2,3, Zhiping Yu1, Xiangqing He1 and Yong Chen2,3; 1Institute of Microelectronics, Tsinghua University, Beijing, China; 2Department of Mechanical and Aerospace Engineering, University of California at Los angeles, Los Angeles, California; 3California NanoSystems Institute, Los Angeles, California.

OO3.8
Bioassays in Freely Suspended Microliter Droplets on a Chip. Vinayak Rastogi and Orlin D Velev; Department of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina.

OO3.9
Nanogap DNA Sensors Fabricated by the Assistance of Angle Evaporation. Han Young Yu, Yong Ju Yun, Chil Seong Ah, Byung Hoon Kim and Soon-Young Oh; ETRI, Daejeon, Korea, South.

OO3.10
Inkjet Printed Peptide/Polymer Hydrogel Microarrays Compatible with On-chip Step-wise Chemical Synthesis, Surface Analysis and Biosensing Honglei Qu1, Nick Locyer2 and Rein V Ulijn1; 1Pure and Applied Chemistry, University of Starthclyde, Glasgow, United Kingdom; 2School of Chemical Engineering and Analytical Science, The University of Manchester, Manchester, United Kingdom.

OO3.11
Abstract Withdrawn

OO3.12
Ion Transport in 2-nm Nanochannels Chuanhua Duan1 and Arun Majumdar1,2; 1Mechanical Engineering, University of California, Berkeley, Berkeley, California; 2Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.

OO3.13
SPR Investigation of Fibrillation Kinetics of Huntingtin Protein Immobilized using Solid-Binding Peptides Sibel Cetinel1,2, Urartu O Seker1,2, Christopher So1, Elvan Arslan2,3, Candan Tamerler1,2, Paul Muchowski4,5 and Mehmet Sarikaya1,2; 1Genetically Engineered Materials Center, University of Washington, Seattle, Washington; 2Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey; 3Molecular and Cell Biology, University Pierre et Marie Curie, Paris VI, Paris, France; 4Gladstone Institute of Neurological Disease, University of California, San Francisco, California; 5Biochemistry and Biophysics, University of California, San Francisco, California.

OO3.14
Portable FET Biosensor Platform for Point-of-care Testing: ``e-SEN" Jong-Heon Yang1, Tae-Youb Kim1, Chang-Geun Ahn1, Chan Woo Park1, Chil Seong Ah1, Ansoon Kim1, In-Bok Baek1, Young-Hwa Kim2, Min-Jun Kim2 and Gun Yong Sung1; 1IT Convergence Technology Research Laboratory, ETRI, Daejeon, Korea, South; 2H3SYSTEM, Daejeon, Korea, South.

OO3.15
Three-dimensional Nano-bio-diagnostic System using Protein Nanoparticle. Eun Jung Lee1, Jin-Seung Park1, Keum-Young Ahn1, Moon Kyu Cho2, Hyuk-Seong Seo1, Jong-Am Song1, Jong-Hwan Lee1, Jae-Uk Shin1, Seong-Eun Kim1, Young Keun Kim2 and Jeewoon Lee1; 1chemical and biological engineering, Korea University, Seoul, Korea, South; 2materials science and engineering, Korea University, Seoul, Korea, South.

OO3.16
Design and Fabrication of Core-shell Microspheres from Microfluidic Approaches. Weijia Wen, Department of Physics and KAUST-HKUST Micro/Nanofluid Joint Laboratory, The Hong Kong University of Science and Technology, Kowloon, China.

OO3.17
Abstract Withdrawn

OO3.18
Abstract Withdrawn

OO3.19
Biohybrid Photoelectrochemical Nanoengineered Interfaces. Arati Sridharan, Jit Muthuswamy and Vincent B Pizziconi; Bioengineering, Arizona State University, Tempe, Arizona.

OO3.20
Biocompatible CNTs as Electrodes for Neural Sensing Shiang-Jie Yen1, Huan-Chieh Su1, Wei-Lun Hsu2, Hsin Chen3, Wei-Leun Fang4, Shih-Rung Yeh2, Yen-Chung Chang2 and Tri-Rung Yew1; 1Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan; 2Life Science, National Tsing Hua University, Hsinchu, Taiwan; 3Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan; 4Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

OO3.21
Fluorescent Gold Cluster coated Magnetic Nanoparticles for Dual Imaging Application Chenjie Xu and Shouheng Sun; SHOUHENG SUN, Brown University, Providence, Rhode Island.

OO3.22
Lipid Peroxidation in Living Cells Promotes Nanosecond Membrane Electropermeabilization. Yu-Hsuan Wu1, Zachary A. Levine2, D. Peter Tieleman3, Martin A. Gundersen4 and P. Thomas Vernier4,5; 1Materials Science and Engineering, University of Southern California, Los Angeles, California; 2Department of Physics and Astronomy,, University of Southern California, Los Angeles, California; 3Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada; 4Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California; 5MOSIS,Information Sciences Institute, University of Southern California, Los Angeles, California.

OO3.23
Competitive Adsorption of Bovine Serum Albumin and Lysozyme on Nano-crystalline Calcium Phosphate Bioceramics. Huijie Zhang, Xiangdong Zhu, Hongsong Fan and Xingdong Zhang; National Engineering Research Center for Biomaterials, Chengdu, Sichuan, China.

OO3.24
Amperometric Glucose Biosensor Based on Pt-dispersed Polyaniline Nanorods on Porous Au Electrode. Min-Jung Song1,2, Sung-Woo Hwang1,2 and Dongmok Whang1,3,4; 1Research Center for Time-domain Nano-functional Devices, Korea University, Seoul, Korea, South; 2School of Electrical Engineering, Korea University, Seoul, Korea, South; 3SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon, Korea, South; 4Materials Science & Engineering, Sungkyunkwan University, Suwon, Korea, South.

SESSION OO4: Materials Synthesis on Chip
Chair: Saif Kahn
Wednesday Morning, April 15, 2009
Room 3016 (Moscone West)

8:30 AM OO4.1
Biofabrication and Enzymatic Functionalization of Free-standing Chitosan Membranes in Microfluidic Network.  Xiaolong Luo1,3, Dean Edward Larios Berlin1,3, Jeffrey Gair1 and Gary Rubloff2,3; 1Bioengineering, University of Maryland, College Park, College Park, Maryland; 2Materials Science, University of Maryland, College Park, College Park, Maryland; 3Institute for Systems Research, University of Maryland, College Park, College Park, Maryland.

8:45 AM OO4.2
Ultra-Soft Microfluidics: Photo-Induced Structures from Lipid Bilayers. Linda S Hirst1 and Jing Yuan2; 1Natural Sciences (physics), UC Merced, Merced, California; 2Physics, Florida State University, Tallahassee, Florida.

9:00 AM OO4.3
Tunable Synthesis of Metallic Nanoparticles in Three-phase Microfluidic Segmented Flows. Saif A. Khan and Suhanya Duraiswamy; Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.

9:15 AM OO4.4
Microscale Bioactive Patterning of Silicone Rubber for Incorporation in Microfluidic Channels Jessica M McLachlan, Natasha Patrito, Sarvesh Varma, Jayna Chan and Peter R Norton; Chemistry, University of Western Ontario, London, Ontario, Canada.

9:30 AM OO4.5
Nanoparticle Synthesis on a Programmable Microfluidic Droplet System. Woon Seob Lee1, Duckjong Kim1, Se-kwon Kim2 and Jong Wook Hong1; 1Materials Research and Education Center, Department of Mechanical Engineering, Auburn University, Auburn, Alabama; 2Marine BioProcess Research Center, Pukyong National University, Busan, Korea, South.

9:45 AM BREAK

10:15 AM OO4.6
Patterning Colloidal Gold Nanoparticles on a Device Surface through Chemical Self Assembly. Sarah Marie Adams and Regina Ragan; Chemical Engineering and Materials Science, University of California, Irvine, Irvine, California.

10:30 AM OO4.7
Directed Fluidic Assembly of Nanotube Networks for Transistors and Aqueous Chemical Sensors Melburne LeMieux, Nishant Patil, Mark Roberts, Stefan Mannsfeld, Justin Opatkiewicz and Zhenan Bao; Chemical Engineering, Stanford, Stanford, California.

10:45 AM OO4.8
The On-chip, Directional Growth of Metallic and Polymeric Nanowires. Bret N Flanders and Prem S Thapa; Physics, Kansas State University, Manhattan, Kansas.

11:00 AM OO4.9
Gradient Lithography of Engineered Proteins to Fabricate Cell Culture Microenvironments. Sheng Wang1,2, Cheryl Wong Po Foo3, Mu-ming Poo4, Sarah C Heilshorn3 and Xiang Zhang1,5; 1NSF Nanoscale Science and Engineering Center (NSEC), University of California Berkeley, Berkeley, California; 2Applied Science and Technology Graduate Program, University of California Berkeley, Berkeley, California; 3Department of Materials Science and Engineering, Stanford University, Stanford, California; 4Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California; 5Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.

11:15 AM OO4.10
Fabrication of Microfluidic Devices for Droplet Generation based on Dry Film Resist Patrick W. Leech1, Nan Wu2 and Yonggang Zhu2; 1CSIRO, Materials Science and Engineering, Clayton, Victoria, Australia; 2CSIRO, Materials Science and Engineering, Highett, Victoria, Australia.

SESSION OO5: Cell Manipulation & Biomimetics on Chip
Chair: Henry Zeringue
Wednesday Afternoon, April 15, 2009
Room 3016 (Moscone West)


1:30 PM OO5.1
Capture and Release of Cardiac Fibroblasts in Microfluidic Devices using Peptide-Functionalized Alginate Gels Brian D Plouffe1, Melissa A Brown2,3, Milica Radisic2,3 and Shashi Murthy1; 1Chemical Engineering, Northeastern University, Boston, Massachusetts; 2Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada; 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

1:45 PM OO5.2
Electronically Modulated Mixing of Neurotransmitters for Spatio-temporal Control of Nerve Cell Signalling Using an Organic Electrophoretic Delivery Device. Karin Larsson1,3, Klas Tybrandt2,3, Sindhulakshmi Kurup1,3, Daniel Simon2,3, Peter Kjäll1,3, Joakim Isaksson2, Edwin Jager2,3, Mats Sandberg4, Magnus Berggren2,3 and Agneta Richter-Dahlfors1,3; 1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden; 2Department of Science and Technology, Linköping University, Norrköping, Sweden; 3Strategic Research Center for Organic Bioelectronics (OBOE), Stockholm, Sweden; 4Acreo AB, Norrköping, Sweden.

2:00 PM OO5.3
Peptide-Functionalized Surfaces in Microfluidic Devices for Cell Separation by Negative Selection James V Green1, Milica Radisic2,3 and Shashi Murthy1; 1Chemical Engineering, Northeastern University, Boston, Massachusetts; 2Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada; 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

2:15 PM OO5.4
Rapid One-step Fabrication of 3D Branched Microvascular Flow Networks in Plastic Substrates. Jen-Huang Huang, Jeongyun Kim, Arul Jayaraman and Victor Ugaz; Chemical Engineering, Texas A&M University, College Station, Texas.

2:30 PM OO5.5
A Chip Based Patch Clamp Device. Piyush Verma and Nick Melosh; Materials Science and Engineering, Stanford University, Stanford, California.

2:45 PM OO5.6
Integrated On-Chip Blood Separation and Cancer Marker Detection Ophir Vermesh and Rong Fan; California Institute of Technology, Pasadena, California.

3:00 PM OO5.7
Critical Size, Dynamic Range, and Throughput Improvements in Sorting by Deterministic Lateral Displacement Enabled by Triangular Posts. Kevin Loutherback1,2, Kevin S Chou2, Jason Puchalla3, Robert H Austin1,3 and James C Sturm1,2; 1Princeton Institute for the Science and Technology of Materials, Princeton University, Princeton, New Jersey; 2Electrical Engineering, Princeton University, Princeton, New Jersey; 3Physics, Princeton University, Princeton, New Jersey.

3:15 PM BREAK

3:30 PM OO5.8
The Normal and Shear Strength of the Cell-Implant Interface: Accelerated Negative Buoyancy as a Method of Cell Adhesion Assessment. Helen Jane Griffiths1, Charles A Collier1, Athina E Markaki1,2, James A Curran1,3 and Trevor W Clyne1; 1Materials Science and Metallurgy, University of Cambridge, Cambridge, United Kingdom; 2Department of Engineering, University of Cambridge, Cambridge, United Kingdom; 3Keronite International Ltd, Cambridge, United Kingdom.

3:45 PM OO5.9
Multiplexed Nanowire Nanoelectronics - Cardiomyocytes Interfaces Tzahi Cohen-Karni2, Brian P Timko1, Lucien E Weiss1 and Charles M Lieber1,2; 1Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts; 2School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts.

4:00 PM OO5.10
Assessing Functional Heterogeneity at Single-cell Level using Integrated Microchips. Rong Fan1,2, Ophir Vermesh1,2, Habib Ahmad1,2, Chao-Chao Liu2, Gabe Kwong1,2 and James R Heath1,2; 1Nanosystems Biology Cancer Center(NSBCC), California Institute of Technology, Pasadena, California; 2Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California.

4:15 PM OO5.11
Femtosecond Laser Ablation to Create Nanometer-scaled Cell Adhesion Ligand Patterns. Ray Schmidt1, David J Hwang2, Naomi T Kohen3, Lara J Gamble4, David G Castner4,5, Costas P Grigoropoulos2 and Kevin E Healy3,1; 1Bioengineering, University of California, Berkeley, Berkeley, California; 2Mechanical Engineering, University of California, Berkeley, Berkeley, California; 3Materials Science and Engineering, University of California, Berkeley, Berkeley, California; 4Department of Bioengineering, National ESCA & Surface Analysis Center for Biomedical Problems, University of Washington, Seattle, Washington; 5Department of Chemical Engineering, National ESCA & Surface Analysis Center for Biomedical Problems, University of Washington, Seattle, Washington.

4:30 PM OO5.12
Bio-inspired Microfluidic Propulsion Through Magnetically-actuated Cilia. Syed N Khaderi1, Michiel Baltussen2, Patrick Anderson2, Daniel Ioan3, Jaap Den Toonder2,4 and Patrick Onck1; 1Zernike Institute for Advanced Materials, University of Groningen, Groningen, Netherlands; 2Eindhoven University of Technology, Eindhoven, Netherlands; 3University Politehnica of Bucharest, Bucharest, Romania; 4Philips Research, Eindhoven, Netherlands.

4:45 PM OO5.13
Thermochemical Nanolithography of Multi-functional Templates for Selective Assembly of Bioactive Proteins. Debin Wang1,3, Vamsi Kodali1,4, William D Underwood2,3, Jonas E Jarvholm2,3, Takashi Okada2,3, Simon C Jones2,3, Mariacristina Rumi2,3, Zhenting Dai5, William P King5, Seth R Marder2,3, Jennifer E Curtis1,4 and Elisa Riedo1,3; 1School of Physics, Georgia Institute of Technology, Atlanta, Georgia; 2School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia; 3Center for Organic Photonics and Electronics, Georgia Institute of Technology, Atlanta, Georgia; 4Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia; 5Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois.

SESSION OO6: Advances in Device Materials
Thursday Morning, April 16, 2009
Room 3016 (Moscone West)

8:00 AM OO6.1
Lab-on-Glass System for DNA Analysis using Thin and Thick Film Technologies. Domenico Caputo1, Matteo Ceccarelli1, Giampiero de Cesare1, Augusto Nascetti2 and Riccardo Scipinotti1; 1Department of Electronic Engineering, University of Rome Sapienza, Rome, Italy; 2Department of Aerospace and Astronautics Engineering, University of Rome Sapienza, Rome, Italy.

8:15 AM OO6.2
Pattern Formation with low Energy Ion Beams. Shikha Varma, Dipak Paramanik, Subrata Majumder and Smruti R Sahoo; Institute of Physics, Bhubaneswar, India.

8:30 AM OO6.3
Fast Prototyping method of Flexible Monolithic COC Chips for High Resolution DNA separation. Sandrine Miserere1, Jérémie Weber2, Jean-Louis Viovy1 and Laurent Malaquin1; 1Institut Curie, Paris, France; 2Fluigent SA, Paris, France.

8:45 AM OO6.4
Low Distortion, High Strength Bonding of Polymer Microfluidic Chips via Case II Diffusion Alfredo Martin Morales, Thomas I Wallow, Blake A Simmons, Karen L Krafcik, Linda A Domeier, Kamlesh D Patel and Andrew D Gardea; Sandia National Laboratories, Livermore, California.

9:00 AM OO6.5
Microfluidic Contact Printing (μf-CP): a Novel Technique for Patterning Biomolecules on Hydrogel Substrates Huaibin Eli Zhang1, Jennifer N Hanson2 and Ralph G Nuzzo1,2; 1Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois; 2Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.

9:15 AM OO6.6
Self-Assembled Ultra-thin Silica Layers for On-Chip Chromatography Sun Choi1, Inkyu Park1,2 and Albert P Pisano1; 1Berkeley Sensor and Actuator Center(BSAC), UC Berkeley, Berkeley, California; 2Mechanical Engineering, KAIST, Daejon, Korea, South.

9:30 AM OO6.7
Textural Guidance Cues for Controlling Process Outgrowth of Mammalian Neurons. Jennifer Nicole Hanson1, Michael J Motala2, Michael L Heien2, Martha Gillette3, Jonathan Sweedler2 and Ralph G Nuzzo2,1; 1Material Science and Engineering, University of Illinois-Urbana Champaign, Urbana, Illinois; 2Chemistry, University of Illinois-Urbana Champaign, Urbana, Illinois; 3Cell and Developmental Biology, University of Illinois-Urbana Champaign, Urbana, Illinois.

9:45 AM OO6.8
Microfluidics with Membranes. Rob Lammertink, Jorrit de Jong and Matthias Wessling; University of Twente, Enschede, Netherlands.

10:00 AM BREAK

SESSION OO7: Novel Materials for Labs on a Chip
Chair: Henry Zeringue
Thursday Morning, April 16, 2009
Room 3016 (Moscone West)

10:30 AM OO7.1
Microfluidic Transport of Liquids in Wrinkle Microstructures. Krishnacharya Khare and Shu Yang; Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania.

10:45 AM OO7.2
Chitosan: A Versatile Platform for Biomolecular Reactions and Sensing in Lab-On-A-Chip Applications. Susan Buckhout-White1,3, Xiaolong Luo2,3, Dean Larios Berlin2,3 and Gary W Rubloff1,3; 1Materials Science and Engineering, University of Maryland, College Park, Maryland; 2Bioengineering, University of Maryland, College Park, Maryland; 3Institute for Systems Research, University of Maryland, College Park, Maryland.

11:00 AM OO7.3
Young’s Modulus of Collagen at Physiologically Relevant Displacement Rates for Mammary Gland Cell Studies in Microfluidic Devices. Maria del Carmen Lopez Garcia, David J Beebe and Wendy C Crone; Material Science Program, University of Wisconsin - Madison, Madison, Wisconsin.

11:15 AM OO7.4
A Conformal Nano-adhesive via Initiated Chemical Vapor Deposition for Microfluidic Devices Sung Gap Im, Ki Wan Bong, Patrick S Doyle and Karen K Gleason; Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

11:30 AM OO7.5
Bioactive Polymer Surfaces as a Novel Fouling Deterrence Strategy. Neeraj V. Gohad1, Nihar M Shah2, Andrew T Metters2 and Andrew S Mount1; 1Biological Sciences, Clemson University, Clemson, South Carolina; 2Bioengineering, Clemson University, Clemson, South Carolina.

SESSION OO8: Advances in Integrating Device Components
Chair: Victor Ugaz
Thursday Afternoon, April 16, 2009
Room 3016 (Moscone West)

1:30 PM OO8.1
The MAESFLO Device: A Complete Microfluidic Control System. Jacques Goulpeau and Velan Taniga; Microfluidic Instrument, FLUIGENT SA, Paris, France.

1:45 PM OO8.2
Electronic Flow Control in Microfluidics Utilizing Surface Energy Switching of Conducting Polymers. Edwin WH Jager1, Anders Hentzell1, Daniel Forchheimer1, Karl Svennersten2, Agneta Richter-Dahlfors2 and Magnus Berggren1; 1Dept. Science & Technology (ITN), Linköping University, Norrköping, Sweden; 2Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

2:00 PM OO8.3
Membrane Chips and Robotics—practical Lipid Bilayer Technologies for Ion Channel Measurements. Jacob Schmidt, Bioengineering, UCLA, Los Angeles, California.

2:15 PM OO8.4
Miniaturization of Immunoassays Using Optical Detection with Integrated Amorphous Silicon Photodiodes. Ana Teresa Pereira1,2, Virginia Chu1, Duarte M. F Prazeres2,3 and João P Conde1,3; 1INESC Microsistemas e Nanotechnologias and IN- Institute of Nanoscience, Lisboa, Portugal; 2Centro de Engenharia Biológica e Química, IBB - Institute of Biotechnology and Bioengineering, Instituto Superior Técnico, Lisboa, Portugal; 3Dept. of Chemical and Biological Engineering, Instituto Superior Técnico, Lisboa, Portugal.

2:30 PM OO8.5
Miniaturized Silicon Apertures for Lipid Bilayer Reconstitution Experiments. Michael Goryll and Nipun Chaplot; Electrical Engineering, Arizona State University, Tempe, Arizona.

2:45 PM BREAK

SESSION OO9: Porous Materials in Labs on a Chip
Chair: Saif Kahn
Thursday Afternoon, April 16, 2009
Room 3016 (Moscone West)

3:15 PM OO9.1
Porous Silicon in Lab-on-a-Chip Technology: Main Features and Applications in Biosensing Platforms. Luca De Stefano, Edoardo De Tommasi, Ilaria Rea and Ivo Rendina; Institute for Microelectronics and Microsystems, National Council for Research, Naples, Italy.

3:30 PM OO9.2
Efficient Nanoporous Silicon Membranes for Integrated Microfluidic Separation and Sensing Systems. Nazar Ileri1,2, Pieter Stroeve1, Sonia E Létant2, Jerald Britten2, Hoang Nguyen2, Cindy Larson2, Saleem Zaidi3, Ahmet Palazoglu1, Roland Faller1 and Joseph W Tringe2; 1University of California Davis, Davis, California; 2Lawrence Livermore National Laboratory, Livermore, California; 3Gratings, Inc., Albuquerque, New Mexico.

3:45 PM OO9.3
Open-Pore Microfluidic Tissue Engineering Scaffolds. George C Engelmayr1, Jane Wang2,3, Jeffrey T Borenstein3, Robert Langer1 and Lisa E Freed1; 1Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts; 2Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; 3Biomedical Engineering Center, Charles Stark Draper Laboratory, Cambridge, Massachusetts.

4:00 PM OO9.4
Sub-5 nm FIB Direct Patterning of Nanopores. Gierak Jacques and Birgitta Schiedt, CNRS-LPN, Marcoussis, France.

4:15 PM OO9.5
Functionalized Porous Nanostructured Thin Films for Immobilization of Biomolecules. Jonathan K Kwan and Jeremy C Sit; Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, Canada.

SESSION OO10: Sensing and Detection on Chip - Molecular Level
Chair: Victor Ugaz
Friday Morning, April 17, 2009
Room 3016 (Moscone West)

8:00 AM OO10.1
Abstract Withdrawn

8:15 AM OO10.2
Abstract Withdrawn

8:30 AM OO10.3
Design and Operation of a Capillary Based Calorimeter for 30uL Liquid Samples for Protein Analysis. Lito Panes de la Rama1, Liang Hu1, Mike Efremov3, Mark McLean2 and Leslie Allen1; 1Materials Science and Engineering, University of Illinois - Urbana Champaign, Urbana, Illinois; 2Biochemistry, University of Illinois - Urbana Champaign, Urbana, Illinois; 3Chemical Engineering, University of Wisconsin - Madison, Madison, Wisconsin.

8:45 AM OO10.4
Abstract Withdrawn

9:00 AM OO10.5
Polymeric Magnetic Microparticles for On-line Detection of Prion Protein in a Microfluidic Chip. Virginie Audonnet1, Anne Le Nel1,2, Myriam Taverna2 and Jean-Louis Viovy1; 1Laboratoire PCC, Institut Curie (UMR CNRS/IC 168), Paris, France; 2JE2495 Protéines et Nanotechnologies en Sciences Séparatives, Université Paris-Sud, Châtenay-Malabry, France.

9:15 AM OO10.6
Label Free, Electrical Detection of the SARS Virus N-Protein Utilizing Carbon Nanotube Biosensors and Peptide Aptamers as Capture Probes Fumiaki Ishikawa1, Hsiao-kang Chang1, Marco Curreli2, Rui Zhang2, Mark Thompson2 and Chongwu Zhou1; 1Department of Electrical Engineering, University of Southern California, Los Angeles, California; 2Department of Chemistry, University of Southern California, Los Angeles, California.

9:30 AM OO10.7
Inorganic Thin Film Transistor Sensors Suitable for Bio-sensing Soumya Dutta, Davianne Duarte and Ananth Dodabalapur; Microelectronics Research Centre, University of Texas at Austin, Austin, Texas.

9:45 AM OO10.8
Plasmonic Nanoholes in a Multi-Channel Microarray Format for Parallel Kinetic Assays and Differential Sensing Hyungsoon Im, Antoine Lesuffleur, Nathan C Lindquist and Sang-Hyun Oh; Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota.

10:00 AM BREAK

SESSION OO11: Sensing and Detection on Chip - Cells & Particles
Chair: Saif Kahn
Friday Morning, April 17, 2009
Room 3016 (Moscone West)

10:30 AM OO11.1
Doped ZnO Colloids for Cancer Detection - Bio-Imaging and Cytotoxicity Study. Linda Y.L. Wu1,2, June G Loh2, Sheng Fu2, Alfred I Tok2, Leong Chuan Kwek2, Xianting Zeng1 and Freddy C Boey2; 1Singapore Institute of Manufacturing Technology, Singapore, Singapore; 2Nanyang Technological University, Singapore, Singapore.

10:45 AM OO11.2
Spatially Localized Quorum Sensing in a Microfluidic Device. Xiaolong Luo1,5, Rohan Fernandes1,2, William E Bentley1,2, Gregory F Payne2, Reza Ghodssi3,5 and Gary W Rubloff4,5; 1Bioengineering, University of Maryland, College Park, Maryland; 2University of Maryland Biotechnology Institute (UMBI), College Park, Maryland; 3Electrical and Computer Engineering, University of Maryland, College Park, Maryland; 4Materials Science and Engineering, University of Maryland, College Park, Maryland; 5Institute for Systems Research (ISR), University of Maryland, College Park, Maryland.

11:00 AM OO11.3
Integration of Collector, On-chip Sample Concentrator, and Capillary Based Contactless Conductivity Detector for Bioparticle Detection. Alfredo Martin Morales1, Josh A Whaley1, Mark D Zimmerman1, Karen L Krafcik1, April Nissen1, Joanne V Volponi1, Scott M Maurer2 and William D Munslow2; 1Sandia National Laboratories, Livermore, California; 2Lockheed Martin MS2, Manassas, Virginia.

11:15 AM OO11.4
Novel DNA Sensor Based on Carbon Nanotube Lab-on-a-Chip. Jessica E. Weber1, Shreekumar Pillai2, Shree R Singh2 and Ashok Kumar1; 1Mechanical Engineering, University of South Florida, Tampa, Florida; 2Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama.

11:30 AM OO11.5
Screen-Grid Field Effect Transistor for sensing Bio-Molecules. Kwee G Eng1, Kristel Fobelets1 and Jesus E Velazquez-Perez2; 1Electrical and Electronic Engineering, Imperial College London, London, United Kingdom; 2Applied Physics Department, University of Salamanca, Salamanca, Spain.

11:45 AM OO11.6
Resonant Microcavities Coupled to Photonic Crystal Waveguides for Multi-channel Biodetection. Elisa Guillermain and Philippe M Fauchet; ECE, University of Rochester, Rochester, New York.

SESSION OO12: Sensing and Detection on Chip: DNA
Chair: Victor Ugaz
Friday Afternoon, April 17, 2009
Room 3016 (Moscone West)

1:30 PM OO12.1
A Picomolar Electrical Platform for Protein and Nucleic Acid Biomarker Detection using Bio-functionalized Microfluidic Channels Mehdi Javanmard2,1, Amirali H Talasaz2,1, Mohsen Nemat-Gorgani1, Fabian Pease2, Mostafa Ronaghi1 and Ronald W Davis2; 1Stanford Genome Technology Center, Stanford University, Palo Alto, California; 2Electrical Engineering, Stanford University, Stanford, California.

1:45 PM OO12.2
Microcantilever Sensor Arrays with Built-in Interferometric Readout. Stephan Koev1, Rohan Fernandes2, William Bentley2 and Reza Ghodssi1; 1Department of Electrical and Computer Engineering, University of Maryland, College Park, Maryland; 2Fischell Department of Bioengineering, University of Maryland, College Park, Maryland.

2:00 PM OO12.3
Study of Capacitance Modulation in Nanoneedle Biosensor for Protein Detection. Hesaam Esfandyarpour1,2, Rahim Esfandyarpour1,2, Mehdi Javanmard1,2, Fabian W Pease1 and Ronald W Davis2; 1Electrical Engineering, Stanford University, Stanford, California; 2Stanford Genome Technology Center, Stanford University, Stanford, California.

2:15 PM OO12.4
Phosphate Terminated Single Strand DNA on Hafnium Oxide for Bio-Sensing Applications. Nicholas Michael Fahrenkopf1, Serge Oktyabrsky1, Eric Eisenbraun1, Magnus Bergkvist1, Hua Shi2 and Nathaniel C Cady1; 1College of Nanoscale Science and Engineering, University at Albany, Albany, New York; 2Department of Biological Sciences, University at Albany, Albany, New York.

2:30 PM OO12.5
DNA Thermosequencing for 1000$/gene-level: A Calorimetric Method for High Throughput Genomics. Hesaam Esfandyarpour1,2, Fabian W Pease2 and Ronald W Davis1; 1Stanford Genome Technology Center, Stanford University, Stanford, California; 2Electrical Engineering, Stanford University, Stanford, California.

2:45 PM BREAK

SESSION OO13: Materials Characterization using Micro- and Nano- Scale Tools
Chair: Henry Zeringue
Friday Afternoon, April 17, 2009
Room 3016 (Moscone West)

3:15 PM OO13.1
Microfluidic Landscaper: Analysis of Intricate Catalytic Performances of an Enzyme. Hoon Suk Rho1, Duckjong Kim1, Doug Goodwin2, Se-Kwon Kim3 and Jong Wook Hong1; 1Materials Research and Education Center, Department of Mechanical Engineering, Auburn University, Auburn, Alabama; 2Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama; 3Marine BioProcess Research Center, Pukyong National University, Busan, Korea, South.

3:30 PM OO13.2
Microfluidic Devices for Rheological Investigations. Salvatore Girardo, Elisa Mele, Roberto Cingolani and Dario Pisignano; NNL CNR-INFM, Lecce, Italy.

3:45 PM OO13.3
Jet Micromixer for Studying Fast Chemical Reactions by Small-Angle X-Ray Scattering Benedetta Marmiroli1, Gianluca Grenci2, Heinz Amenitsch1, Barbara Sartori1, Fernando Cacho-Nerin1, Peter Laggner1 and Luca Businaro2; 1Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Graz, Austria; 2Lilit Micro-Nanofabrication Laboratory, Trieste, Italy.

4:00 PM OO13.4
Surface-Enhanced Raman Spectroscopy of DNA. Aoune Barhoumi1, Dongmao Zhang2, Felicia Tam3 and Naomi Halas2,1; 1Chemistry, Rice University, Houston, Texas; 2Electrical and Computer Engineering, Rice University, Houston, Texas; 3Physics Department, Rice University, Houston, Texas.

4:15 PM OO13.5
Electrical Enhancement of DNA Hybridization and Melting at Surfaces. Ian Y Wong1, Nazanin Davani2 and Nicholas A Melosh1; 1Materials Science and Engineering, Stanford University, Stanford, California; 2Chemical Engineering, Stanford University, Stanford, California.

4:30 PM OO13.6
Quartz Crystal Microbalance-Dissipation and Reflectometry to Monitor in Situ the Structural Transformation of Lipid Vesicles to a Bilayer on a Gold Surface. Nam-Joon Cho1, Guoliang Wang2, Malin Edvardsson2, Jeffrey Glenn1, Fredrik Hook2 and Curtis W Frank3; 1Division of Gastroenterology, Stanford University, Stanford, California; 2Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden; 3Department of Chemical Engineering, Stanford University, Stanford, California.



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