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Symposium LL: Orthopaedic/Dental Biomaterials

* Invited paper

This symposium endorsed by the Society for Biomaterials

SESSION LL1: ORTHOPAEDIC/DENTAL TISSUE ENGINEERING
Chair: C. Mauli Agrawal
Monday Morning, November 27, 2000
Berkeley (Sheraton)

8:30 AM *LL1.1
STRUCTURAL TEMPLATES AND BIOREACTORS FOR CARTILAGE TISSUE ENGINEERING. Gordana Vunjak-Novakovic and Lisa E. Freed, Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, MA.

9:00 AM LL1.2
FORMATION OF THREE DIMENSIONAL CELL-POLYMER CONSTRUCTS IN BIOREACTORS FOR BONE TISSUE ENGINEERING. Vassilios Sikavitsas, Gregory Bancroft, Antonios Mikos, Rice University, Dept of Bioengineering, Houston, TX.

9:15 AM LL1.3
DEVELOPMENT OF A NOVEL PHOTOCROSSLINKABLE HYALURONAN MATRIX FOR CARTILAGE REPAIR. Kimberly A. Smeds, Duke Univ, Dept of Chemistry, Durham, NC; Jean Y. Wang, Anthony E. Baer, Lori A. Setton, Duke Univ, Dept of Biomedical Engineering, Durham, NC; Mark W. Grinstaff, Duke Univ, Depts of Chemistry and Ophthalmology, Durham, NC.

9:30 AM LL1.4
CHITOSAN/TRICALCIUM PHOSPHATE SCAFFOLDS FOR BONE TISSUE ENGINEERING. Yong Zhang, Miqin Zhang, University of Washington, Dept of Materials and Engineering, Seattle, WA.

9:45 AM BREAK

10:15 AM LL1.5
CONTROLLING DIFFUSION OF SOLUTES THROUGH IONICALLY CROSSLINKED ALGINATE HYDROGELS DESIGNED FOR TISSUE ENGINEERING. Catherine K. Kuo, Peter X. Ma, Univ of Michigan, Dept of Biologic and Materials Sciences, Macromolecular Science and Engineering Center, Dept of Biomedical Engineering, Ann Arbor, MI.

10:30 AM LL1.6
DEVELOPMENT OF BIODEGRADABLE POLYMER SCAFFOLDS FOR TISSUE ENGINEERING USING CO-EXTRUSION TECHNIQUES. Newell R. Washburn, Alamgir Karim, Eric J. Amis, National Institute of Standards and Technology, Gaithersburg, MD; Kimberlee Potter, National Institutes of Health, Bethesda, MD.

10:45 AM LL1.7
TEMPORARY ENCAPSULATION OF RAT MARROW OSTEOBLASTS IN GELATIN MICROSPHERES FOR BONE TISSUE ENGINEERING. R.G. Payne¹, A.W. Yasko², M.J. Yaszemski³ and A.G. Mikos¹. ¹Inst. of Biosciences and Bioengineering, Rice University, Houston, TX. ²Dept. of Ortho- paedics, M.D. Anderson Cancer Center, Houston, TX. ³Dept. of Orthopaedics, Mayo Clinic, Rochester, MN.

11:00 AM LL1.8
DESIGNING BIOMATERIALS FOR USE IN BONE. Kenneth James, Howard Levene, Joachim Kohn, Department of Chemistry, Rutgers University, Piscataway, NJ; J. Russell Parsons, Department of Orthopaedics, UMD-New Jersey Medical School, Newark, NJ.

11:15 AM LL1.9
A COLLAGEN/HYALURONATE BILAYER MATRIX FOR TISSUE REPAIR. Lin-Shu Liu, Andrea Y. Thompson, Robert C. Spiro, Orquest, Inc. Mountain View, CA.

11:30 AM *LL1.10
RECONSTITUTING THE STRUCTURE AND INFORMATION CONTENT OF ACTUAL TISSUE SCAFFOLDS. Eugene Bell.

SESSION LL2: DENTAL/MAXILLOFACIAL BIOMATERIALS
Chair: John Brunski
Monday Afternoon, November 27, 2000
Berkeley (Sheraton)

1:30 PM *LL2.1
OVERVIEW OF DEVICE RETRIEVAL AND ANALYSIS. Jack Lemons, University of Alabama at Birmingham, Department of Dental Biomaterials, Birmingham, AL.

2:00 PM LL2.2
DESIGN AND CHARACTERIZATION OF NEW Ti-Ag AND Ti-Ag-Sn ALLOYS FOR CRANIO-MAXILLO-FACIAL PROSTHESES MADE BY THREE-DIMENSIONAL PRINTING. Sang-Bum Hong, Harvard School of Dental Medicine, Boston, MA; Noam Eliaz, Gary G. Leisk, Ronald M. Latanision, Massachusetts Institute of Technology, H.H. Uhlig Corrosion Laboratory, Cambridge, MA; Emanuel M. Sachs, Massachusetts Institute of Technology, Dept of Mechanical Engineering, Cambridge, MA; Samuel M. Allen, Massachusetts Institute of Technology, Dept of Materials Science and Engineering, Cambridge, MA.

2:15 PM LL2.3
STRUCTURE-NANOMECHANICAL PROPERTY STUDY IN ENAMEL USING MOLECULAR APPROACHES VIA BIOMIMETICS. Hanson Fong and Mehmet Sarikaya, Materials Science and Engineering, University of Washington, WA; Michael L Paine, Wen Luo and Malcolm L. Snead, The Center for Craniofacial Molecular Biology, School of Dentistry, The University of Southern California, Los Angeles, CA; Shane N. White, School of Dentistry, University of California, Los Angeles, CA.

2:30 PM LL2.4
IN VIVO STUDY OF BIOACTIVE GLASS PASTE IN MOLARS OF MINI-PIGS. Sarah E. Efflandt, Lorraine F. Francis, University of Minnesota, Dept of Chemical Engineering and Materials Science, Minneapolis, MN; Manuela Lopes, Jorge Perdigao, William H. Douglas, University of Minnesota, Minnesota Dental Research Center for Biomaterials and Biomechanics, Minneapolis, MN; Ching-Chang Ko, University of Minnesota, Department of Oral Science, Minneapolis, MN.

2:45 PM BREAK

3:15 PM LL2.5
APATITE GROWTH ON BIOACTIVE GLASSES IN ARTIFICIAL SALIVA. Sarah E. Efflandt, Robert F. Cook, Lorraine F. Francis, University of Minnesota, Dept of Chemical Engineering and Materials Science, Minneapolis, MN.

3:30 PM LL2.6
SYNTHESIS AND CHARACTERISATION OF HYDROXYAPATITE FROM MELLITE EDUARDO BARROSOI SP. NOV. AND MONETITE. V. Rodriguez-Lugo, G.A. Camacho-Bragado, J.A. Ascencio, C. Angeles-Chavez, V.M. Castao.

3:45 PM LL2.7
ATOMIC SCALE INTERFACIAL STRUCTURE OF HYDROXY- APATITE: HIGH-RESOLUTION TRANSMISSION ELECTRON MICROSCOPY. Kimiyasu Sato¹, Toshihiro Kogure^1,2, Toshiyuki Ikoma^1,3, Yuri Kumagai¹ and Junzo Tanaka^1,3. ¹CREST, Japan Science and Technology, Saitama, JAPAN. ²Department of Earth and Planetary Science, Graduate School of Science, University of Tokyo, Tokyo, JAPAN. ³National Institute for Research in Inorganic Materials, Ibaraki, JAPAN.

4:00 PM LL2.8
THE NANOSCALE MECHANICAL PROPERTIES OF HUMAN MOLAR DENTAL ENAMEL. Adrian B. Mann, Suhn Kim, Janet Cuy, Ken Livi, Mark Teaford, Timothy P. Weihs, The Johns Hopkins University, Dept of Materials Science and Engineering, Baltimore, MD.

4:15 PM LL2.9
MAXILLOFACIAL IMPLANTS OF POLARIZED HYDROXY- APATITE PLASMA-SPRAY-COATING TITANIUM. Hideki Sagawa, Takayuki Kobayashi, Masato Ueshima, Satoshi Nakamura, Masataka Ohgaki, Kimihiro Yamashita, Tokyo Medical and Dental Univ, Inst of Biomaterials and Bioengineering, Tokyo, JAPAN.

4:30 PM LL2.10
DESIGNING MONOLAYER DENTAL CERAMIC CROWN STRUCTURES. Yan Deng, Hae-Won Kim, Young-Woo Rhee and Brian R. Lawn, National Institute of Standards and Technology, Materials Science and Engineering Laboratory, Gaithersburg, MD.

4:45 PM LL2.11
CONTACT DAMAGE MODES IN MULTILAYERED STRUCTURES FOR DENTAL APPLICATIONS. Pedro Miranda, Fernando Guiberteau, Universidad de Extremadura, Dept Electrónica e Ingeniería Electromecánica, Badajoz, SPAIN; Antonia Pajares, Francisco L. Cumbrera, Universidad de Extremadura, Dept Física, Badajoz, SPAIN; Brian R. Lawn, Materials Science and Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, MD.

SESSION LL3: ORTHOPAEDIC BIOMATERIALS
Chair: Orhun K. Muratoglu
Tuesday Morning, November 28, 2000
Berkeley (Sheraton)

8:30 AM *LL3.1
Harry Rubash

9:00 AM LL3.2
STRUCTURE AND PROPERTIES OF A NEW NANOCOMPO- SITE POLY(METHYL METHACRYLATE) BONE CEMENT. Anuj Bellare, Andreas Gomoll, Wolfgang Fitz, Richard D. Scott, Thomas S. Thornhill, Dept of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; David A. Baker, Lisa A. Pruitt, Dept of Mechanical Engineering, University of California at Berkeley, Berkeley, CA.

9:15 AM LL3.3
COMPARATIVE EARLY STAGE MINERALIZATION ADJACENT TO PROSTHETIC IMPLANTS IN CANINE- AND HUMAN- MODEL BONE EXPLANTS. Alexandra Porter, Cambridge University, Dept of Materials Science & Metallurgy, Cambridge, UNITED KINGDOM; Melanie J. Coathup and Gordon W. Blunn, Royal Orthopaedic Hospital, Biomedical Engineering Centre, Stanmore, Middx, UNITED KINGDOM; Myron Spector, Brigham & Women's Hospital and Harvard Medical School, Department of Orthopaedic Research, Boston, MA; Linn W. Hobbs, MIT, Dept of Materials Science & Engineering, Cambridge, MA.

9:30 AM LL3.4
BIOLOGICAL REACTION OF POLARIZED HYDROXYAPATITE PROSTHESIS IN BONE MARROW. Tomoko Sakai^{1, 2}, Takayuki Kobayashi¹, Masato Ueshima¹, Satoshi Nakamura¹, Sadao Morita², Ken-ichi Shinomiya², Kimihiro Yamashita¹, Tokyo Medical and Dental Univ. ¹Institute of Biomaterials and Bioengineering. ²Dept of Orthopedics, Tokyo, JAPAN.

9:45 AM BREAK

10:15 AM LL3.5
STRENGTH AND TOUGHNESS OF AN APATITE CEMENT. Victoria C. Jew, Reinhold H. Dauskardt, Stanford Univ, Dept of Materials Science and Engineering, Stanford, CA.

10:30 AM LL3.6
INFLUENCE OF HIGH SPEED MIXING ON AGGLOMERATION OF NANOMETER BARIUM SULFATE IN BONE CEMENT. Wolfgang Fitz, Andreas Gomoll, Anuj Bellare, Richard D. Scott, Thomas S. Thornhill Orthopaedic Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

10:45 AM LL3.7
CONDITIONS LEADING TO INCREASED INTERFACIAL POROSITY IN CEMENTED FEMORAL STEMS. Stephen Spiegelberg, Cambridge Polymer Group, Inc., Somerville, MA.

11:00 AM LL3.8
BIOACTIVITY RESPONSES OF DIFFERENT UHMWPE PARTICLES FROM IN-VIVO AND IN-VITRO TESTS. YoungSoo Park, Stephen Hsu, National Institute of Standards and Technology, Gaithersburg, MD; Sang Y. Yang, P. Wooley, Wayne State University, Detroit, MI; K. Merritt, U.S. Food and Drug Administration, Rockville, MD; Michael J. McNallan, University of Illinois at Chicago, Chicago, IL.

11:15 AM LL3.9
MECHANISM OF OSTEOGENESIS AROUND POLARIZED HYDROXYAPATITE IMPLANTS. Takayuki Kobayashi, Satoshi Nakamura, Masato Ueshima, Kimihiro Yamashita, Tokyo Medical and Dental Univ, Inst of Biomaterials and Bioengineering, Tokyo, JAPAN.

11:30 AM *LL3.10
EVALUATION OF ARTIFICIAL KNEE JOINTS. Peter Walker.

SESSION LL4: MUSCULOSKELETAL BIOMATERIALS
Chair: Warren O. Haggard
Tuesday Afternoon, November 28, 2000
Berkeley (Sheraton)

1:30 PM *LL4.1
MUSCULOSKELETAL TISSUE ENGINEERING: CLINICAL AND BIOMATERIALS CONSIDERATIONS. Mike Yaszemski, Mayo Clinic.

2:00 PM LL4.2
STEREOLITHOGRAPHIC PROCESSING OF CERAMIC/ ORGANIC COMPOSITES FOR ORTHOPAEDICS. Jim H. Lee, Robert K. Prud'homme and Ilhan A. Aksay, Princeton University, Dept. of Chemical Engineering and Princeton Materials Institute, Princeton, NJ.

2:15 PM LL4.3
PROCESSING AND PROPERTIES OF NANOSTRUCTURED HYDROXYAPATITE-BASED BIOMATERIALS FOR ORTHO- PEDIC APPLICATIONS. Edward Ahn, Jackie Ying, Massachusetts Institute of Technology, Dept of Chemical Engineering, Cambridge, MA; Myron Spector, Harvard Medical School, Dept of Orthopedic Surgery, Boston, MA.

2:30 PM LL4.4
MICROPATTERNED SURFACES MODIFIED WITH SELECT PEPTIDES PROMOTE EXCLUSIVE INTERACTIONS WITH OSTEOBLASTS. M.E. Hasenbein, S.C. Deslandes, T.T. Andersen*, R. Bizios, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY. *Department of Biochemistry and Molecular Biology, Albany Medical College, Albany, NY.

2:45 PM BREAK

3:15 PM LL4.5
MECHANICAL BEHAVIOUR OF POLY-HYDROXY- ALKANOATES/HYDROXYAPATITE COMPOSITES AS BONE IMPLANT BIOMATERIALS. Ruben Sanchez, Marcio Moriera, Norma Galego, Polymer Section, Advanced Materials Laboratory, North Fluminense State University, UENF; Campos dos Goytacazes, RJ, BRAZIL.

3:30 PM LL4.6
A NOVEL COMPOSITE BIOMATERIAL FOR APPLICATIONS INVOLVING ELECTRICAL STIMULATION OF BONE. Peter Supronowicz, Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, NY; Pulickel Ajayan, Rensselaer Polytechnic Institute, Department of Materials Science and Engineering, Troy, NY; Klaus Ullmann, Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, NY; Bernard Arulanandam, Dennis Metzger, Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY; Rena Bizios, Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, NY.

3:45 PM LL4.7
FABRICATION AND CHARACTERISATION OF CALCIUM PHOSPHATE AND LIPOSOMES COMPOSITES AS AN IMPLANT COATING. Tarinee Pongsaanutin, Jan T. Czernuszka, Department of Materials, University of Oxford, Oxford, UNITED KINGDOM.

4:00 PM LL4.8
TRANSFORMATION BEHAVIOUR, MECHANICAL PROPERTIES AND BIOCOMPATIBILITY OF A BINARY NiTi AND A TERNARY NiTiCu ALLOY. Mohammed Es-Souni, University of Applied Sciences, Materials Testing and Joining, Kiel, GERMANY; Martha Es-Souni, Helge Fischer-Brandies, Clinic of Orthodontics, Christian-Albrechts University, Kiel, GERMANY.

4:15 PM LL4.9
NANOCERAMICS AS THE FUTURE ORTHOPAEDIC/DENTAL BIOMATERIAL. Thomas J. Webster, Richard W. Siegel*, Rena Bizios, Departments of *Materials Science and Engineering and Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.

4:30 PM LL4.10
SYNTHESIS AND CHARACTERIZATION OF CORALLINE HYDROXYAPATITE GRAFTED WITH PMMA FUNCTIONAL MICROSPHERES FOR OSTEOGENIC AND BONE FILLING MATERIALS. M. Sivakumar and K. Panduranga Rao, Biomaterials Laboratory, Central Leather Research Institute, Adyar, Chennai, INDIA.

SESSION LL5: POSTER SESSION
ORTHOPAEDIC/DENTAL BIOMATERIALS
Tuesday Evening, November 28, 2000
8:00 PM
Exhibition Hall D (Hynes)

LL5.1
POLYURETHANE BIOMATERIALS WITH ANTI-INFECTION PROPERTIES. Erkesh O. Batyrbekov, Rinat M. Iskakov, Bulat A. Zhubanov, Institute for Chemical Sciences, Almaty, KAZAKSTAN.

LL5.2
NOVEL POLYMER/CERAMIC NANOCOMPOSITES FOR ORHOPAEDIC/DENTAL APPLICATIONS: MECHANICAL AND CYTOCOMPATIBILITY PROPERTIES. Anastasia J. McManus, Richard W. Siegel*, Robert H. Doremus*, Rena Bizios, Rensselaer Polytechnic Institute, Departments of Biomedical Engineering and *MS&E, Troy, NY.

LL5.3
PHYSICAL AND MECHANICAL PROPERTIES OF A PHOTOCROSSLINKED HYALURONAN FOR BIOMEDICAL APPLICATIONS. Kimberly A. Smeds and Mark W. Grinstaff, Duke University, Department of Chemistry, Durham, NC.

LL5.4
EFFECTS OF DEMINERALISED BONE MATRIX IMPLANTS FOR FRACTURE HEALING IN CANINES. R.V. Suresh Kumar, Department of Surgery and Radiology, College of Veterinary Science, Tirupati, INDIA.

LL5.5
PHOTOCROSSLINKED POLY(PROPYLENE FUMARATE) SCAFFOLDS FOR ORTHOPEDIC APPLICATIONS. John P. Fisher, Theresa A. Holland, Antonios G. Mikos, Rice University, Department of Bioengineering, Houston, TX.

LL5.6
FABRICATION OF AN INJECTABLE POROUS BIODEGRADABLE HYDROGEL FOR DENTAL TISSUE ENGINEERING. Esfandiar Behravesh, Antonios G. Mikos, Rice Univ, Dept of Bioengineering, Houston, TX.

SESSION LL6: NOVEL ORTHOPAEDIC/DENTAL BIOMATERIALS
Chair: Joachim Kohn
Wednesday Morning, November 29, 2000
Berkeley (Sheraton)

8:30 AM *LL6.1
POSTERIOR ALL-CERAMIC CROWNS - A DAMAGE/FATIGUE PROBLEM. Van Thompson, University of Medicine and Dentistry of New Jersey, NJ.

9:00 AM LL6.2
DESIGN, SYNTHESIS AND CHARACTERIZATION OF HYDROXYAPATITE PARTICULATES. Chun-Wei Chen, Kullaiah Byrappa, Charles Oakes, Wojciech Suchanek, Richard Riman, Rutgers Univ, Dept of Ceramic and Materials Engineering, Piscataway, NJ; Mamoru Senna, Keio Univ, Faculty of Science and Technology, Yokohama, JAPAN; Kelly Brown, Kevor TenHuisen, Victor Janas, Johnson & Johnson Corp Biomaterials Center, Somerville, NJ.

9:15 AM LL6.3
EFFECTS OF DOPING SUBSTITUTIONS IN HYDROXYAPATITE ON OSTEOBLAST ADHESION. Thomas J. Webster, Celaletdin Ergun*, Robert H. Doremus*, Rena Bizios, Departments of Biomedical Engineering and *Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy, NY.

9:30 AM BREAK

10:00 AM LL6.4
A BIOACTIVE GLASS FIBER REINFORCED COMPOSITE. Anthony B. Brennan, Univ of Florida, MS&E and Biomed Eng, Gainesville, FL; Rodrigo Orefice, Fed Univ of Minas Gerais, Dept of Metl and Mater Eng, Belo Horizonte-MG, BRAZIL; A.E. Clark, Univ of Florida, Prosth Dept, Gainesville, FL; Larry L. Hench, Imperial College, London, UNITED KINGDOM.

10:15 AM LL6.5
SYNTHETIC BIODEGRADABLE POLYMER NETWORKS MODULATING MARROW STROMAL OSTEOBLAST FUNCTION. Heungsoo Shin, Antonios G. Mikos, Dept of Bioengineering, Houston, TX.

10:30 AM LL6.6
CRYSTAL MORPHOLOGY CONTROL BY MELT PHASE SEPARATION IN BIODEGRADABLE POLYMER BLENDS. Yvonne A. Akpalu, Rensselaer Polytechnic Institute, Department of Chemistry, Troy, NY; J. Carson Meredith, Georgia Institute of Technology, School of Chemical Engineering, Atlanta, GA; Eric J. Amis, Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD.

10:45 AM LL6.7
NON-WOVEN SHEETS OF BIOACTIVE FIBERS PRODUCED BY A SOL-GEL PROCESS. Rosana Domingues, Universidade Federal de Minas Gerais, Dept of Chemistry, BRAZIL; Arthur Clark, University of Florida, College of Dentistry, FL; Anthony Brennan, Dept of MS&E, University of Florida, FL.

11:00 AM LL6.8
SYNTHESIS OF NOVEL POLYSACCHARIDE MIMICS. Matthew T. Sheehy, Elisabeth B. Walsh and Mark W. Grinstaff, Duke Univ, Dept of Chemistry, Durham, NC.

11:15 AM LL6.9
SURFACE TREATMENT OF BIOMEDICAL POLYMERS FOR ENHANCED ADHESION. Valerie Barron, Dept of Physics, Trinity College Dublin, IRELAND; Martin Buggy, Dept of Materials Science and Technology, University of Limerick, IRELAND.

11:30 AM LL6.10
THE SYNTHESIS OF HYDROXYAPATITE / POLYSACCHARIDES NANOCOMPOSITES THROUGH A SELF-ORGANIZATION MECHANISM. Toshiyuki Ikoma^1,2 and Junzo Tanaka^1,2. ¹National Institute for Research in Inorganic Materials, Ibaraki, JAPAN. ²CREST, Japan Science and Technology, Saitama, JAPAN.




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See page 7 for a complete list of exhibitors.