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Symposium U: Advanced Materials for Neuroprosthetic Interfaces

Symposium U: Advanced Materials for Neuroprosthetic Interfaces Image
April 11 - 12, 2007
Chairs
Daryl R. Kipke     University of Michigan
Stephanie P. Lacour     University of Cambridge
Barclay Morrison     Columbia University
Dustin Tyler     Case Western Reserve University

Symposium Support
ALA Scientific Instruments, Inc.
Advanced Bionics Corporation
Multi Channel Systems GmbH
Plexon, Inc.


* Invited paper

SESSION U1: Surface Bio-Functionalization
Chair: Barclay Morrison
Wednesday Morning, April 11, 2007
Room 2010 (Moscone West)

8:30 AM *U1.1
Modulate Cortical Tissue Response to Chronic CNS Electrode via Surface Immobilization of Anti-inflammatory Neuropeptide Wei He, George C. McConnell, Thomas Schneider and Ravi V Bellamkonda; Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia.

9:00 AM U1.2
Simultaneous Controlled-Release of Multiple Compounds from the Surface of an Implantable Neural Device. Catherine Lo1, Paul Van Tassel2 and Mark Saltzman1; 1Biomedical Engineering, Yale University, New Haven, Connecticut; 2Chemical Engineering, Yale University, New Haven, Connecticut.

9:15 AM U1.3
``Click" Functionalization of Vapor Deposited Polymer Thin Films for Patterned Surface Modification of Neural Recording Arrays William Shannan O'Shaughnessy1, Nuria Mari-Buye2 and Karen K Gleason1; 1Chemical Engineering, MIT, Cambridge, Massachusetts; 2Chemistry, Institut Quimic de Sarria, Barcelona, Spain.

9:30 AM *U1.4
Improving Biocompatibility of the Neural Probes by Surface Immobilization of Biomolecules Xinyan Tracy Cui, Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania.

10:00 AM BREAK

SESSION U2: Electrode Materials and Functionalization
Chair: Karen Gleason
Wednesday Morning, April 11, 2007
Room 2010 (Moscone West)

10:30 AM U2.1
Characterization of Reactively Sputtered Iridium Oxide Films for Neural Stimulation. Sandeep Negi1, Rajmohan Bhandari1, Richard A Normann2 and Florian Solzbacher1,2,3; 1Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah; 2Department of BioEngineering, University of Utah, Salt Lake City, Utah; 3Department of Materials Science and Engineering, University of Utah, Salt Lake City, Utah.

10:45 AM U2.2
Electroactive Polymers for Neural Interfaces - New Materials Maria Lisa Margareta Asplund1, Elin Thaning1, Hans von Holst1 and Olle Inganäs2; 1School of Technology and Health, Royal Institute of Technology, Huddinge, Sweden; 2Applied Physics, Department of Physics, Chemistry and Biology, Linköping, Sweden.

11:00 AM *U2.3
Biologically-Functionalized and Biologically-Derived Conducting Polymers for Interfacing Biomedical Devices with Living Tissue David Charles Martin1,2,3, Laura Povlich2, Mohammad Abidian3, Jeffrey L. Hendricks3, Sarah Spanninga2, Rickard Axelsson4, Jae Cheol Cho1 and Jinsang Kim1,2,3; 1Materials Science and Engineering, The University of Michigan, Ann Arbor, Michigan; 2Macromolecular Science and Engineering, The University of Michigan, Ann Arbor, Michigan; 3Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan; 4Applied Physics, University of Linkoping, Linkoping, Sweden.

11:30 AM *U2.4
Electrically-conductive Micropatterns that Promote Cell Adhesion and Neurite Extension. G. Tayhas R. Palmore, Sung-Yeol Kim, Hyun-Kon Song and Diane Hoffman-Kim; Brown University, Providence, Rhode Island.

SESSION U3: Electrode Materials and Encapsulation
Chair: Dustin Tyler
Wednesday Afternoon, April 11, 2007
Room 2010 (Moscone West)

1:30 PM *U3.1
Neuronal Interfacing Using Vertically Aligned Carbon Nanofiber Arrays. Nance Ericson1, Timothy McKnight1, Anatoli Melechko2, Charles Britton1, Simpson Michael2, Zhe Yu3 and Barclay Morrison3; 1Engineering Science & Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; 2Material Science & Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; 3Biomedical Engineering Department, Columbia University, New York, New York.

2:00 PM U3.2
A Novel Carbon Nanotube Nano-probe Su Huan-Chieh and Yew Tri-Rung; National Tsing-Hua University, Hsinchu, Taiwan.

2:15 PM U3.3
Vertically-Aligned Carbon Nanofiber Array as a 3D Multifunctional Material for Neural Electrical Interfaces Jun Li1, Barbara T.D. Nguyen-Vu1, Edward de Asis2, Hua Chen1, Alan M. Cassell1, Russell J. Andrews1, Cary Y. Yang2 and M. Meyyappan1; 1NASA Ames Research Center, Moffett Field, California; 2Center for Nanostructures, Santa Clara University, Santa Clara, California.

2:30 PM *U3.4
Biopassivation Coatings by Initiated Chemical Vapor Deposition from Trivinyltrimethylcyclotrisiloxane. W. Shannnan O’Shaughnessy1, David J. Edell2 and Karen K. Gleason1; 1Chemical Engineering, MIT, Cambridge, Massachusetts; 2InnerSea Technology, Bedford, Massachusetts.

3:00 PM BREAK

SESSION U4: Encapsulation Materials
Chair: Ravi Bellamkonda
Wednesday Afternoon, April 11, 2007
Room 2010 (Moscone West)

3:30 PM U4.1
A Biomimetic Approach to Adaptive Nanocomposites for Cortical Electrodes Dustin J. Tyler1,3, Jeffrey R Capadona1,2,3, Otto van den Berg2, Stuart J. Rowan2,1 and Christoph Weder2,1; 1L. Stokes CVAMC, Cleveland, Ohio; 2Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio; 3Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

3:45 PM U4.2
Advances in Encapsulating Elastically Stretchable Microelectrode Arrays. Oliver Graudejus1, Candice Tsay1, Zhe Yu2, Barclay Morrison2, Stephanie P. Lacour3 and Sigurd Wagner1; 1Electrical Engineering, Princeton University, Princeton, New Jersey; 2Department of Biomedical Engineering, Columbia University, New York, New York; 3Department of Materials Science, University of Cambridge, Cambridge, United Kingdom.

4:00 PM U4.3
PECVD Silicon Carbide as a Thin Film Packaging Material for Microfabricated Neural Electrodes Allison Hess, Jiangang Du and Christian Zorman; Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio.

4:15 PM U4.4
Assessment of Biocompatibility of Photosensitive Polyimide for Implantable Medical Device Use Yun Sun1, Roger A Brooks2, Stephanie P Lacour1 and Ruth E Cameron1; 1Materials Science and Metallurgy, University of Cambridge, Cambridge, United Kingdom; 2Orthopaedic Research Unit, University of Cambridge, Cambridge, United Kingdom.

4:30 PM U4.5
Parylene-enabled Flexible Technologies for Neural Prostheses Yu-Chong Tai, Damien Rodger and Wen Li; EE and BE, Caltech, Pasadea, California.

SESSION U5: Poster Session
Chairs: Ravi Bellamkonda and Dustin Tyler
Wednesday Evening, April 11, 2007
8:00 PM
Salon Level (Marriott)


U5.1
Functionalized Poly(3,4-ethylenedioxythiophene) for Bio-electrode Coatings. Laura Kristin Povlich1, Jae Cheol Cho2, Jinsang Kim1,2,3 and David C. Martin1,2,3; 1Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan; 2Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan; 3Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

U5.2
PEDOT-coated, BDNF-secreting Cochlear Implants for Improved Spiral Ganglion Stimulation. Jeffrey L Hendricks1, Jennifer A Chikar2, Sarah M Richardson-Burns3, Yehoash Raphael4, Bryan E Pfingst5 and David C Martin1,3,6; 1Biomedical Engineering, University of Michigan, Ann Arbor, Michigan; 2Neuroscience, University of Michigan, Ann Arbor, Michigan; 3Materials Science & Engineering, University of Michigan, Ann Arbor, Michigan; 4Otolaryngology, University of Michigan, Ann Arbor, Michigan; 5Otorhinolaryngology, University of Michigan, Ann Arbor, Michigan; 6Macromolecular Science & Engineering, University of Michigan, Ann Arbor, Michigan.

U5.3
A PDMS-based Elastic Multi-Electrode Array for Spinal Cord Surface Stimulation and Its Electrode Modification to Enhance Performance. Liang Guo, Kathleen K. Williams, Rick Giuly and Stephen P. DeWeerth; Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia.

U5.4
Thin TiO2 Coatings for Neural Cell Growth Nieves Casan-Pastor1, Jorge Eduardo Collazos-Castro2, Monica Carballo2, Monica Lira-Cantú1, Angel Perez1 and Josep Bassas3; 1Solid State Chemistry and Cristalography, Institut de Ciencia de Materials de Barcelona, CSIC, Bellaterra, Barcelona, Spain; 2Hospital Nacional de Paraplejicos, Toledo, Castilla La Mancha, Spain; 3Serveis Cientifico tecnics, University of Barcelona, Barcelona, Barcelona, Spain.

U5.5
Rutile Substrata for Neural Cell Growth Jorge Eduardo Collazos-Castro1, Berta Moreno-Burriel1, Monica Carballo-Vila1, Eva Chinarro2, Nieves Casañ-Pastor2 and Jose Ramon Jurado-Egea2; 1Neural Repair Laboratory, Hospital Nacional de Paraplejicos, Toledo, Spain; 2Ceramics and Glasses Institute, CSIC, Madrid, Spain.

U5.6
A Combinatorial Approach Towards Functionalizing Copolymers with Effector Molecules that Attenuate Cyto-inflammatory Responses at the Biotic-abiotic Interface. Erik Pierstorff and Dean Ho; Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, Illinois.

U5.7
Electrostatic Potential Mapping and Spatial Resolution at the Visual Prosthesis/Vitreous Humor Interface. Charlene Sanders1, James D. Weiland2, Mark S. Humayun2 and Elias Greenbaum1; 1Oak Ridge National Laboratory, Oak Ridge, Tennessee; 2Doheny Eye Institute, Los Angeles, California.

U5.8
Characterization of Degradation Mechanisms in Neural Recording Electrodes. Jennifer M. Anton and Stephanie A. Hooker; Materials Reliability Division, National Institute of Standards and Technology, Boulder, Colorado.

U5.9
Mechanisms of Mass Transport During Actuation of Poly(3, 4-ethylene dioxythiophene) (PEDOT) using a Quartz Crystal Microbalance for Neural Drug Delivery Devices Rickard E.G. Axelsson1, Mohammad R. Abidian2, Peter Keshtkar3 and David C. Martin2,4,5; 1Department for Applied Physics, University of Linköping, Linköping, Sweden; 2Biomedical Engineering, University of Michigan, Ann Arbor, Michigan; 3Green Hills School, Ann Arbor, Michigan; 4Materials Science & Engineering, University of Michigan, Ann Arbor, Michigan; 5Macromolecular Sciences & Engineering, University of Michigan, Ann Arbor, Michigan.

U5.10
Induction of Presynaptic Complexes by Microscale Patterns of Neuroligin Peng Shi and Lance Kam; Biomedical Engineering, Columbia University, New York, New York.

U5.11
Abstract Withdrawn

SESSION U6: Compliant Neural Devices: New Process Fabrication
Chair: Stephanie Lacour
Thursday Morning, April 12, 2007
Room 2010 (Moscone West)


NOTE EARLY START

8:00 AM *U6.1
Neuro-technical Interfaces based on Biocompatible Polymeric Substrates. Thomas Stieglitz, Department of Microsystems Engineering, University of Freiburg - IMTEK, Freiburg, Germany.

8:30 AM U6.2
Transformation of Silicone Rubber under YAG Laser Irradiation : First Step towards a New Miniaturized Nerve Electrode Fabrication Process. Catherine Dupas-Bruzek1, Odile Robbe2, Ahmed Addad3, Sylvia Turrell2 and Dominique Derozier1; 1Centre d'Etudes et de Recherches Lasers et Applications, Universite des Sciences et Technologies de Lille, Villeneuve d'Ascq, France; 2Laboratoire de Spectroscopie Infrarouge et Raman, Universite des Sciences et technologies de Lille, Villeneuve d'Ascq, France; 3Laboratoire de Structures et Proprietes de l'Etat solide, Universite des Sciences et technologies de Lille, Villeneuve d'Ascq, France.

8:45 AM U6.3
Morphology and Stretchability of Thin Film Metal Conductors on Elastomeric Substrates. Candice Tsay1, Oliver Graudejus1, Sigurd Wagner1, Stéphanie P. Lacour2 and Barclay Morrison3; 1Electrical Engineering, Princeton University, Princeton, New Jersey; 2Materials Science, University of Cambridge, Cambridge, United Kingdom; 3Biomedical Engineering, Columbia University, New York, New York.

9:00 AM U6.4
Metallized Silicone Rubber (PDMS) for Implantable Electrodes. Stephane Befahy1,2, Sami Yunus1, Patrick Bertrand1 and Michel Troosters2; 1Physical Chemistry and Physics of Materials (PCPM), Université catholique de Louvain, Louvain-la-Neuve, Belgium; 2Neurotech SA, Louvain-la-Neuve, Belgium.

9:15 AM U6.5
Design and Fabrication of Compliant Neural Implants for Nerve Repair. Raghied Atta1, Edward Tarte1, James Fitzgerald2, Stephanie Lacour3, Mark Blamire3 and James Fawcett2; 1E E &C Engineeirng, The university of Birmingham, Birmingham, United Kingdom; 2Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom; 3Materials Science, University of Cambridge, Cambridge, United Kingdom.

9:30 AM *U6.6
SiC/Parylene C based Encapsulation for Next Generation Chronic Wireless Neural Interfaces. Florian Solzbacher1,2,3, JuiMei Hsu2, Loren Reith1, Michael Toepper1,4 and Richard A. Normann3; 1Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah; 2Materials Science and Engineering, University of Utah, Salt Lake City, Utah; 3Bioengineering, University of Utah, Salt Lake City, Utah; 4Fraunhofer Institute for Reliability and Microintegration IZM, Berlin, Germany.

10:00 AM BREAK

SESSION U7: Guiding Neurons
Chair: X. Cui
Thursday Morning, April 12, 2007
Room 2010 (Moscone West)

10:30 AM *U7.1
Multicomponent, Biomolecularly-inspired Surfaces for Advanced Guidance of Neurons. Lance Cameron Kam, Biomedical Engineering, Columbia University, New York, New York.

11:00 AM U7.2
Aligned Conducting Polymer Nanotubes for the Controlled Release of Neurotrophins and Contact Guidance of Regenerating Neurons Mohammad Reza Abidian1, Luis Salas1, Timothy Marzullo2, Sarah Marie Richardson-Burns3, Joseph Michael Corey6, Daryl Rickard Kipke1,5 and David Charles Martin1,3,4; 1Biomedical Engineering, University of Michigan, Ann Arbor, Michigan; 2Neuroscience, University of Michigan, Ann Arbor, Michigan; 3Materials Science & Engineering, University of Michigan, Ann Arbor, Michigan; 4Macromolecular Science & Engineering, University of Michigan, Ann Arbor, Michigan; 5Electrical Engineering & Computer Science, University of Michigan, Ann Arbor, Michigan; 6Neurology, University of Micgigan, Ann Arbor, Michigan.

11:15 AM U7.3
A Process for Templating Nerve Guidance Scaffolds with Precision, Highly-ordered, High-aspect ratio Architectures. Jeff S Sakamoto1, Jim Weiss1, Todd Holt3, David Welker3, Shula Stokols2, Tom Gros2 and Mark Tuszynski2; 1JPL/Caltech, Pasadena, California; 2Neuroscience Department, UC San Diego, San Diego, California; 3Paradigm Optics Inc., Pullman, Washington.

11:30 AM *U7.4
Abstract Withdrawn


SESSION U8: Listening to Neurons
Chair: Daryl Kipke
Thursday Afternoon, April 12, 2007
Room 2010 (Moscone West)

1:30 PM *U8.1
Implantable Biomimetic Electronics as Neural Prostheses for Lost Cognitive Function. Theodore Berger, Department of Biomedical Engineering, University of Southern California, Los Angeles, Pennsylvania.

2:00 PM U8.2
Finite Element Modelling of Axonal Amplifiers. James John FitzGerald1, Stephanie P Lacour2, Stephen B McMahon3 and James W Fawcett1; 1Centre for Brain Repair, Cambridge University, Cambridge, Cambridgeshire, United Kingdom; 2Department of Materials Science, Cambridge University, Cambridge, Cambridgeshire, United Kingdom; 3Department of Physiology, King's College London, London, London, United Kingdom.

2:15 PM U8.3
Neural Microcontacts with Wire Electrodes and Woven Logic Maria Lisa Margareta Asplund1, Mahiar Hamedi2, Olle Inganäs2, Robert Forchheimer3 and Hans von Holst1; 1School of Technology and Health, Royal Institute of Technology, Huddinge, Sweden; 2Linköping University, Department of Physics, Chemistry and Biology, Linköping, Sweden; 3Linköping University, Department of Electrical Engineering, Linköping, Sweden.

2:30 PM U8.4
Towards the Formation of Neuro-transistor Artificial Chemical Synapse. Shlomo Yitzchaik1, Ilya Goykhman1, Nina Korbakov1, Carmen Bartic2, Gustaaf Borghs2, Micha Spira1 and Joseph Sappir1; 1Chemistry, Biology and Engineering, The Hebrew University, Jerusalem, Israel; 2Cell Based Sensors & Circuits, IMEC, Lueven, Belgium.

2:45 PM U8.5
Fabrication of CMOS Compatible Sub-micron Nails for On-chip Phagocytosis. Roeland P. Huys1,2, Carmen Bartic1, Bart Van Meerbergen1,3, S. Yitzchaik4, Micha Spira5, J. Shappir6 and Gustaaf Borghs1,3; 1MCP, IMEC, Leuven, Belgium; 2Applied sciences, K.U.Leuven, Leuven, Belgium; 3Science, K.U.Leuven, Leuven, Belgium; 4Inorganic & Analytical Chemistry, Hebrew University of Jerusalem, Jerusalem, Israel; 5Neurobiology, Hebrew University of Jerusalem, Jerusalem, Israel; 6School of Applied Physics, Hebrew University of Jerusalem, Jerusalem, Israel.

3:00 PM BREAK

SESSION U9: Integrated Designs and Devices
Chair: David Martin
Thursday Afternoon, April 12, 2007
Room 2010 (Moscone West)

3:30 PM *U9.1
Development of Neuroelectronic Interfaces for Repair of Damage to the Peripheral Nervous System. Stephen McMahon, Wolfson CARD, King's College London, London, United Kingdom.

4:00 PM U9.2
Stretchable Microelectrode Arrays: Potential for a Highly Compliant Neural Interface. Zhe Yu1, Oliver Graudejus2, Candice Tsay2, Stéphanie P. Lacour3, Sigurd Wagner2 and Barclay Morrison1; 1Biomedical Engineering, Columbia University, New York, New York; 2Electrical Engineering, Princeton University, Princeton, New Jersey; 3Materials Science, University of Cambridge, Cambridge, United Kingdom.

4:15 PM U9.3
Neurofluidic System for Neural Cell Experiments to Investigate the Mechanisms of Deep Brain Stimulation. Michel Decre1, Lucia Cinque1, Sebastien Popoff1, Ger J.A. Ramakers2 and Enrico Marani3; 1Healthcare Devices and Instrumentation, Royal Philips n.v., Eindhoven, Netherlands; 2Netherlands Institute for Neuroscience, Amsterdam, Netherlands; 3University of Twente, Enschede, Netherlands.

4:30 PM *U9.4
New Horizons for Orthotic & Prosthetic Technology. Hugh Herr, Media Lab, MIT, Cambridge, Massachusetts.



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