The Materials Genome Initiative (MGI) was announced in 2011 fueling the era of Materials by Design which combines theory, computation, experiment and data sciences to accelerate materials development and deployment.1 However, for new materials to help in addressing overarching societal challenges as envisioned by the MGI, these new materials must be integrated into Solutions (or Devices) by Design. This need is now increasingly recognized as evinced by recent academic and funding agency workshops aimed at bringing MGI-inspired research approaches to more applied technology development. To get to the desired Devices by Design capability, the domain of predictive theory and high-throughput experiment, currently focused on bulk material properties, must be extended to include interfaces, metastable materials and process optimization. In addition, there is still much foundational development to be done in the basic science and methodologies of Materials by Design. In short, both the breadth and depth of these approaches are improving rapidly. This symposium will bring together specialists and newcomers from academia, national laboratories, industry and government to further this development.