2018 MRS Fall Meeting Home

Symposium BM05—Advanced Manufacturing Technologies for Emulating Biological Tissues

It is increasingly recognized that conventional oversimplified cell cultures based on the conventional planar, static format cannot reproduce the functions of complex biological tissues. Miniaturized biomimetic tissue models fabricated using advanced materials, when interconnected together in a microfluidic circuit, can faithfully recapitulate the structure, physiology, compartmentalization, and interconnectivity of human organ systems. These systems potentially enable accurate prediction of human responses towards pharmaceutical compounds, and the development and testing of nanomedicines, chemicals, and even biological species. In the past decade, advances in materials and microfluidics technologies have facilitated the development of tissue models as simple, reproducible, and scalable platforms that recapitulate tissue-level functions, by incorporation of biological materials such as cells, their associated matrices, and microenvironmental cues. The utilization of fluids in micro-sized channels is cost-effective due to reductions in the amounts of cells, animals, and reagents used, making it potentially scalable. In a related way, different biofabrication techniques have enabled the creation of biomimetic microenvironments to emulate architectural fidelity, apply shear stress, strain, and/or interfaces on different biological materials. The advances in materials will continue to drive the future biological relevance of biomimetic tissue models by contributing to better extracellular matrix-mimicking cues, while biofabrication will enable improved structural control and dynamics required for the successful creation of the complex human tissue microenvironments. This symposium will cover interdisciplinary topics spanning from materials science, physics, chemistry, engineering, biological sciences, and medicine with an emphasis on advanced manufacturing technologies for generating microphysiological systems, for applications in both fundamental studies and translational research.

Topics will include:

  • Microfabrication technologies for generating organoids
  • 3D bioprinting for organoid fabrication
  • Biofabrication for disease modeling
  • Understanding material-cell interactions for engineering tissue models
  • Microfluidics and on-chip technologies for biological applications
  • Multi-organ systems that enable inter-tissue interactions
  • Sensor technologies and materials for monitoring organoid responses
  • Scaling laws that translate the human system into the miniaturized systems through materials designs
  • Computational methods for guiding materials designs
  • A tutorial complementing this symposium is tentatively planned.

Invited Speakers:

  • Mario Alvarez (Monterrey Institute of Technology and Higher Education, Mexico)
  • Jeffery Borenstein (Draper Laboratories, USA)
  • Guohao Dai (Northeastern University, USA)
  • Dongeun (Dan) Huh (University of Pennsylvania, USA)
  • Monica Laronda (Northwestern University, USA)
  • Shoji Takeuchi (Tokyo University, Japan)
  • Yanlei Yu (Fudan University, China)

Symposium Organizers

Yu Shrike Zhang
Harvard Medical School

Guohao Dai
Northeastern University
Department of Bioengineering

Qihui Shi
Shanghai Jiao Tong University
Shanghai Center for Systems Biomedicine
86-21-3420 6104, qihuishi@sjtu.edu.cn

Weijia Zhang
Fudan University
Department of Chemistry and Institute of Biomedical Science
86-21-6564 2009, weijiazhang@fudan.edu.cn

Keywords for Abstract Submission

Bioanalysis, Biofabrication, Bioprinting, Microfluidics, Microphysiological systems, Organ-on-chip, Tissue models