Materials by Design is rapidly becoming a reality, and has sparked public interest as evidenced by the Materials Genome Initiative. The past 3 years have seen innovations in strategies and techniques for materials development and discovery, however, there are still a great many challenges to overcome. New tools for high-throughput first-principles theory have resulted in multiple databases for theory based material properties. These database tools have yet to be properly integrated with experimental materials synthesis and evaluation, with theory providing guidance to the experimentalist while experimental data provides necessary input for improved theoretical predictions. This need is spurring new concerted efforts between theoreticians and experimentalists to develop collaborative models and readily accessible databases of both theoretical and experimental results. In the process of developing new integrated strategies, key advances have also been made in the core fields of high-throughput theory, combinatorial materials synthesis and evaluation, data handling, data mining, and design of experiments. This symposium will bring together specialists and newcomers from academia, national laboratories, and industry to present the lattest advances and discuss pressing challenges to high-throughput materials innovation.