Symposium NM07—Nanostructure-Based Optical Bioprobes – Advances, Trends and Challenges in Optical and Multimodular Bioimaging and Sensing

Bioimaging is a vital tool in the fields of biology and medicine. Among the various imaging methods available for clinical use and in research, such as radiation-based or magnetic resonance imaging, optical imaging is a highly complementary technique due to the possibility to acquire data at high speed and to detect dynamic processes. Seeking deep-tissue optical imaging at high spatial resolution, the ability of the applied light to penetrate the biological tissue is a most significant parameter. In this context, the near-infrared (NIR) region from 700 to 1870 has clearly been identified as the wavelength region of choice. Yet, the development of advanced biocompatible probes showing bright NIR emission under NIR excitation is crucial in order to bring optical deep-tissue imaging to the next level, and cutting-edge research is conducted around the world focussing on novel optical probes, including lanthanide-doped inorganic nanostructures, single-wall carbon nanotubes, and innovative quantum dots (QDs). Beyond optical techniques, the concept of multimodality is receiving increasing attention given that multimodal imaging is a powerful tool combing the advantages of several imaging methods (e.g. optical, MRI, CT, ultrasound, PET, SPECT) while overcoming their individual intrinsic limitations. Addressing this trend, it is the particular aim of this symposium to bring together experts from different fields to foster interdisciplinary exchange eventually resulting in more powerful tools. Major (yet not the sole) focus will be set on the application oriented design of novel probe materials seeking deep-tissue high resolution imaging, improved biocompatibility, smart assembly of multiple functionalities in one multimodular nanocarrier resulting in more reliable theranostic or sensing tools and better understanding of nano-bio-interactions, as well as improved targeting capabilities and controlled biodistribution when seeking in-vivo application. Thus, the goal of this symposium is to present and discuss the most recent achievements, trends, and remaining challenges regarding advanced probe design, characterization and in-vitro / in-vivo application.

Topics will include:

  • Optical bioprobes operating in the NIR region (e.g. lanthanide based, QDs, carbon based structures, group IV elements, dyes)
  • Smart surface modification and recent advances in molecular probes for targeted imaging
  • Nanostructures for optical biosensors: measuring pH, temperature and chemical compounds at the nanoscale
  • Multiplexed biosensors
  • Nanocarriers for light-triggered therapeutics
  • Enhanced probe properties through multi-structure assembling (e.g., plasmon enhancement, antenna effects, etc.)
  • Overcoming toxicity concerns in e.g., heavy-metal based probes
  • Novel heavy-metal free quantum dots for biomedical application
  • Multimodal approaches combing e.g., optical, magnetic and radiation based probes
  • Short and long-term biodistribution of nanostructured bioprobes and in-vivo applications

Invited Speakers:

  • Luís D. Carlos (Universidade de Aveiro, Portugal)
  • Allison Dennis (Boston University, USA)
  • Jennifer Dionne (Stanford University, USA)
  • Hans-Heine Gorris (University Regensburg, Germany)
  • Alexander Govorov (Ohio University, USA)
  • Daniel Jaque (Universidad Autónoma de Madrid, Spain)
  • Kazunori Kataoka (University of Tokyo, Japan)
  • Bin Liu (National University of Singapore, Singapore)
  • Igor L. Medintz (U.S. Naval Research Laboratory, USA)
  • Teri W. Odom (Northwestern University, USA)
  • Fiorenzo Omenetto (Tufts University, USA)
  • Lora Ramunno (University of Ottawa, Canada)
  • Javier Reguera (Centro de Investigación Cooperativa en Biomateriales biomaGUNE, Spain)
  • Ute Resch-Genger (Federal Institute for Materials Research and Testing (BAM), Germany)
  • Adam Shuhendler (University of Ottawa, Canada)
  • Kohei Soga (Tokyo University of Science, Japan)
  • Tero Soukka (University of Turku, Finland)
  • Francesco Stellacci (École Polytechnique Fédérale de Lausanne, Switzerland)

Symposium Organizers

Eva Hemmer
University of Ottawa
Chemistry and Biomolecular Sciences
Canada
1-613-562-5800-1987, ehemmer@uottawa.ca

Niko Hildebrandt
Université de Paris Sud
Institut d’Électronique Fondamentale
France
33-1-69-15-55-81, niko.hildebrandt@u-psud.fr

Jianghong Rao
Stanford University School of Medicine
Department of Radiology and Chemistry
USA
650-736-8563, jrao@stanford.edu

Fiorenzo Vetrone
Université de Québec - Instutitut National de la Recherche Scientifique
Centre Énergie Matériaux Télécommunication
Canada
1-450-9298247, vetrone@emt.inrs.ca