MRS Meetings and Events


EL17.07.02 2023 MRS Fall Meeting

3D Microporous Ti3C2TX MXene for Electrochemical Sensing of Antibiotics in Tissue Engineered Scaffolds

When and Where

Nov 28, 2023
2:15pm - 2:30pm

Hynes, Level 2, Room 208



Anand Tiwari1,Katie Hixon1,William J. Scheideler1

Dartmouth College1


Anand Tiwari1,Katie Hixon1,William J. Scheideler1

Dartmouth College1
3D continuous mesoscale architectures of nanomaterials provide opportunities to enhance performance and integration of electrochemical biosensors through control over the distribution of active sites and facilitation of ion transport. We present 3D printed microporous electrochemical biosensors integrating biocompatible 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub> MXenes to monitor antibiotic drug release in tissue engineering scaffolds. The 3D microporous Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub> MXene is synthesized by a simple deposition of MXene ink on a microscale 3D-printed polymer scaffold coated in conductive ZnO:Al. Due to the microporous hybrid structure of Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub> MXene, direct electron transfer is facilitated and the 3D biosensors displayed efficient detection of common antibiotics such as gentamicin and vancomycin. The engineered 3D pore structure exposes more electrochemically active surfaces of MXene, resulting in remarkable sensitivity for detecting gentamicin concentrations from 10 nM to 1 mM and vancomycin concentrations from 100 nM to 1 mM, which are 1000 times more sensitive than planar 2D films of MXene. Additionally, this study characterized the suitability of these implantable sensors for bone tissue regeneration applications. Osteoblast-like (MG-63) cells are seeded on the microporous 3D MXene architectures for 3, 5, and 7 days. An increased concentration of cells is noted over the 7 days along both the edges and pores where MXene had been deposited, demonstrating biocompatibility and clinical translation potential. Based on these results, this combination of 3D scaffolds with biocompatible 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub> MXene materials can provide a platform for mediator-free biosensing, enabling new applications for <i>in vivo</i> monitoring of drug elution.



Symposium Organizers

Majid Beidaghi, University of Arizona
Abdoulaye Djire, Texas A&M University
Xuehang Wang, Delft University of Technology
Seon Joon Kim, Korea Institute of Science and Technology

Symposium Support

Nanoplexus Limited

King Abdullah University of Science
MSE Supplies LLC

Publishing Alliance

MRS publishes with Springer Nature