The symposium solicits recent developments in molecular engineering of interfacial regions in (bio)organic-inorganic, ceramic, and multi-component polymer systems, local morphology characterization, and property evaluation using experiment, simulation, and approaches based on artificial intelligence. Tailoring the interphases may include grafting to/from, layer-by-layer assembly, physical vapor deposition, and self-assembly. Advances are specifically invited in electron microscopy (STEM, EELS, and electron tomography), scanning probe microscopy (AFM, AFM-IR, peak force, K-AFM, SThm-AFM, C-AFM), fluorescence microscopy, spectroscopy, and nano X-ray tomography to visualize and assess morphology-property relationships at multiple length scales. In parallel, new developments in data analysis, autonomous optimization, and multiscale simulation (quantum-mechanical, atomistic, coarse-grained) are solicited for better understanding of molecular interactions, chemical reaction kinetics, growth of different phases (nodules, amorphous, crystalline, interdigitated) and property predictions. Properties may include, for example, glass transition temperatures, melting, modulus, toughness, conductivity (electrical/thermal), plasmonic, and luminescence. Joint experimental-computational contributions that advance the area of high strength fiber-reinforced composites, intelligent bioinspired materials, biomedical materials, multifunctional composites and batteries are encouraged. Advances in in-situ experiments based on scanning probe microscopy and electron microscopy to understand nanoscale confinement, intrinsic toughening mechanisms, and locally probe damage at the nanoscale are solicited. Advances in the synthesis, modelling, characterization, and design principles of bio-nano interfaces are welcome, including components of machine learning and artificial intelligence techniques to optimize mechanical, thermal, electronic, photonic, and sensor properties.