Symposium SM01—Organ-on-a-Chip—Toward Personalized Precision Medicine
Miniaturization techniques ushered by nanotechnology have resulted in engineering new concepts and applications in cell biology. This trend has inspired the cell architects to conceive novel ideas. One such incredible device architecture is an organ-on-chip (OOC). Essentially, OOC attempts to fulfill the long sought desire of researchers who have imagined to recreate tissues and organs by etching grooves on silicon or plastic wafers to engineer a microenvironment that mimics the complex and physiological conditions in real organs. 3D extracellular matrix and multicellular spheroids are used to study the diverse functionality in human body with biomedical, chemical, pharmaceutical and environmental perspectives. All these methods serve as indispensable tools to investigate biological processes at cellular and tissue levels through controllable environment in vitro, but these models fall short to recapture the complex physiological functions of an organ. Ultimately in vivo methods involving animal models are exclusive choice to emulate and predict human responses to antigens, drugs or chemicals. However, they still have a few pitfalls like high cost, long study duration, ethical aspects, and its inability to foresee human response quite often that lowers the credibility of the animal testing. OOC allows the integration, automation and parallelization of biochemical processes apart from the miniaturization aspect. Organ on a Chip: Towards Personalized Medicine MRS Spring 2020 brings together physicians, basic scientists, point of care devices mimicking organs like pancreas, material science, microfluidics, biomedical and pharmaceutical companies, Federal agencies - FDA, Center for Disease Control, in a single forum.