Meetings & Events

 

2015 MRS Fall Meeting Logo2015 MRS Fall Meeting & Exhibit

November 29-December 4, 2015 | Boston
Meeting Chairs: T. John Balk, Ram Devanathan, George G. Malliaras, Larry A. Nagahara, Luisa Torsi

Symposium K : Materials Science, Technology and Devices for Cancer Modeling, Diagnosis and Treatment

2015-11-30   Show All Abstracts

Symposium Organizers

Tony Dickherber, National Cancer Institute
Rong Fan, Yale University
Sharon Gerecht, Johns Hopkins University
Sebastian Maerkl, Ecole Polytechnique Federale de Lausanne
Miqin Zhang, University of Washington
K2: Advancing Liquid Biopsies in the Clinic
Session Chairs
Sebastian Maerkl
Rong Fan
Monday PM, November 30, 2015
Hynes, Level 3, Room 301

2:30 AM - *K2.01
Magnetic Ranking Cytometry for Ultrasensitive Analysis of Heterogeneous CTCs

Reza M. Mohamadi 1 Shana O. Kelley 1

1University of Toronto Toronto Canada

Show Abstract

3:00 AM - *K2.02
Affinity Selection of Rare Circulating Tumor Cells (CTCs) For Cancer Diagnostics Using Polymer Microfluidics: Is the Role of the Polymer Material Important?

Steven Allan Soper 1

1University of North Carolina Chapel Hill United States

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3:30 AM - *K2.03
Rare Circulating Tumor Cell (CTC) Capture Using Micro-Patterned Silicon Nanowire Platform and Its Drug Response of Captured CTCs within Cancer Patient Bloods

Sang-Kwon Lee 1 Dong-Joo Kim 3 Mun-Ki Choi 1 Jin-Tak Jeong 1 Wonshik Han 2

1Chung-Ang University Seoul Korea (the Republic of)2Seoul National University College of Medicine Seoul Korea (the Republic of)3UNIST Ulsan Korea (the Republic of)

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4:00 AM -
BREAK

4:30 AM - *K2.04
Cancer Cell Migration in 3D

Denis Wirtz 1 Pei-Hsun Wu 1

1Johns Hopkins University Baltimore United States

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5:00 AM - K2.05
Microfluidics Technology for Cancer Diagnosis & Personalized Treatment

Chwee Teck Lim 1

1National University of Singapore Singapore Singapore

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5:15 AM - K2.06
In Situ Electrochemical ELISA for Specific Identification of Captured Cancer Cells

Tina Saberi Safaei 1 Reza M. Mohamadi 2 Edward H. Sargent 1 Shana O. Kelley 2 3 4

1University of Toronto Toronto Canada2University of Toronto Toronto Canada3University of Toronto Toronto Canada4University of Toronto Toronto Canada

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5:30 AM - K2.07
Identification of Various Stages of Induced Apoptosis and Treatment Sensitivity in Non-Small Cell Lung Carcinoma Using Dielectrophoresis

Rajeshwari Taruvai Kalyana Kumar 1 Shanshan Liu 2 John D. Minna 2 Shalini Prasad 1

1Univ of Texas-Dallas Richardson United States2University of Texas Southwestern Medical College Dallas United States

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5:45 AM - K2.08
Microfluidic Device Based on Tunable Thermo-Responsive Polymer-Graphene Oxide (GO) Composite Film for Efficient CTC Isolation and Enumeration

Apoorv Shanker 1 Hyeun Joong Yoon 2 Yang Wang 2 Molly Kozminsky 2 Qu Jin 2 Nallasivam Palanisamy 8 Monika Burness 3 Ebrahim Azizi 3 Diane Simeone 3 Max Wicha 3 Jinsang Kim 4 1 5 Sunitha Nagrath 2 6 7

1University of Michigan Ann Arbor United States2University of Michigan Ann Arbor United States3University of Michigan Ann Arbor United States4University of Michigan Ann Arbor United States5University of Michigan Ann Arbor United States6University of Michigan Ann Arbor United States7University of Michigan Ann Arbor United States8Henry Ford Health System Detroit United States

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K3: Poster Session I: Advancing Basic Cancer Research Capabilities
Session Chairs
Sebastian Maerkl
Miqin Zhang
Monday PM, November 30, 2015
Hynes, Level 1, Hall B

9:00 AM - K3.01
Enhancement of the Photoactivity RuO2 Doped Nanoparticles TiO2 Supported on Disordered Mesoporous Silica as Photocatalyts for Methylene Blue Photodegradation

Yuliana de Jesus Acosta-Silva 1 Arturo Mendez-Lopez 1

1CINVESTAV Distrito Federal Mexico

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9:00 AM - K3.02
Mesoporous Fe2O3/CdS Heterostructures for Real-time Photoelectrochemical Dynamic Probing of Cu2+

Jun Li 1 Jing Tang 1 Yongcheng Wang 1 Gengfeng Zheng 1

1Fudan University Shanghai China

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9:00 AM - K3.03
Nanoporous GaN Substrates for Directing Stem Cell Function and Differentiation

Lin Han 1 Jing Zhou 1 Yubing Sun 2 Yu Zhang 3 Jung Han 3 Jianping Fu 2 Rong Fan 1

1Yale University New Haven United States2University of Michigan Ann Arbor United States3Yale University New Haven United States

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9:00 AM - K3.04
Microchip Platforms for Multiplex Measurement of microRNA Biomarkers in Single Cells

Nayi Wang 1 Yu Wu 1 Yao Lu 1 Steve Chapin 2 Patrick S. Doyle 2 Jun Lu 1 Rong Fan 1

1Yale University New Haven United States2MIT Cambridge United States

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9:00 AM - K3.05
Cancer Detection from Breath: Aldehyde Sensing by Microsensor Arrays

Andreas Guentner 1 Samuel Regli 1 Kiran Chikkadi 1 Vitaly Koren 1 Marco Righettoni 1 Sotiris E Pratsinis 1

1ETH Zurich Zurich Switzerland

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9:00 AM - K3.06
A Microchip Platform to Monitor Proliferation and Protein Fluctuation of Individual Cancer Cells

Iva Xhangolli 1 Franziska Michor 2 3 Rong Fan 1

1Yale University New Haven United States2Dana-Farber Cancer Institute Boston United States3Harvard T.H. Chan School of Public Health Boston United States

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9:00 AM - K3.07
Functional Nanoparticles for SERS Imaging and Detection of Biomolecular Activities

Zakiya Skeete 1 Jing Li 1 Christian Salazar 1 Alice Wu 1 Xavier Hamilton 1 Christopher Manahan 1 Jin Luo 1 Chuan-Jian Zhong 1

1SUNY-Binghamton Binghamton United States

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K1: Novel Materialsmdash;Enabled Treatment Strategies I
Session Chairs
Tony Dickherber
Rong Fan
Monday AM, November 30, 2015
Hynes, Level 3, Room 301

10:00 AM - *K1.01
Nanopore-Based Detection of Biomarker toward Cancer Diagnostics

Rashid Bashir 1

1University of Illinois at Urbana - Champaign Urbana United States

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10:30 AM - *K1.02
Measuring Kinase Activity in Living Cells with Chemical Biology

Laurie Parker 1

1University of Minnesota Minneapolis United States

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11:00 AM -
BREAK

11:30 AM - K1.03
Electrical Monitoring of 3D Cell Models Using Organic Electronics

Vincenzo Curto 1 Miriam Huerta 1 Jonathan Rivnay 1 Adel Hama 1 Roisin Owens 1

1Ecole des Mines-St. Etienne Gardanne France

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11:45 AM - K1.04
Synthesis Strategies to Achieve Optimal Pd@Au Core-Shell Radioactive Nanoparticles for Medical Physics (Brachytherapy) Applications

Myriam Laprise-Pelletier 1 2 3 Marc-Andre Fortin 1 2 Jean Lagueux 2 Marie-France Cote 2 Pascale Chevallier 2 3

1Universite Laval Quebec Canada2CR-CHU de Quebec Quebec Canada3Centre Quebecois des Mateacute;riaux Fonctionnels (CQMF) Quebec Canada

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12:00 PM - K1.05
Engineering Gold -Silver Based Theragnostic Nanocages for Combinatorial Therapy of Breast Cancer

Sreejith Raveendran 1 Anindito Sen 2 Toru Maekawa 1 Sakthi Kumar 1

1Toyo University, Bionano Electronics Research Center Saitama Japan2JEOL Limited Tokyo Japan

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12:15 PM - K1.06
Cancer Cell Membrane-Coated Gold Nanorods as Theranostic Agents for Cancer Therapy

Valeria Marangoni 1 Juliana Cancino 1 Valtencir Zucolotto 1

1Univ de Sao Paulo Sao Carlos Brazil

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12:30 PM - K1.07
Biosynthesis of Magnetite Nanoparticles for Specific Targeting of Breast Cancer Cells

John David Obayemi 1 2 Winston O Soboyejo 1 2 Olushola S Odusanya 2 Karen Malatesta 1

1Princeton University Princeton United States2African University of Science and Technology, AUST Abuja Nigeria

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12:45 PM - K1.08
Synthesis and Characterization of Poly(1,2-glycerol carbonate)-Graft-Succinic Acid-Paclitaxel Conjugate Nanoparticles

Iriny Ekladious 1 Heng Zhang 1 Mark W Grinstaff 1

1Boston Univ Boston United States

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2015-12-01   Show All Abstracts

Symposium Organizers

Tony Dickherber, National Cancer Institute
Rong Fan, Yale University
Sharon Gerecht, Johns Hopkins University
Sebastian Maerkl, Ecole Polytechnique Federale de Lausanne
Miqin Zhang, University of Washington
K5: Materials and Devices Driving Basic Cancer Research
Session Chairs
Miqin Zhang
Sebastian Maerkl
Tuesday PM, December 01, 2015
Hynes, Level 3, Room 301

2:30 AM - *K5.01
Biomimetic Hydrogels to Study Tumor Biology and Tumor Angiogenesis

Jennifer L. West 1 Laila C. Roudsari 1

1Duke University Durham United States

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3:00 AM - *K5.02
Mapping the ldquo;Dark Matterrdquo; of Genome - Complex Structural Variations and Towards True Contiguity of de novo Genome Assembly with Nanochannel Technology

Han Cao 1

1Bionano Genomics San Diego United States

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3:30 AM - *K5.03
Interplay of Genes, Anatomy, and Tissue Mechanics in Cancer

Jan Liphardt 1 Rajarshi Ghosh 1 Quanming Shi 1 Matt Franklin 1 Valerie Weaver 2

1Stanford University Stanford United States2University of California, San Francisco San Francisco United States

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4:00 AM -
BREAK

4:30 AM - K5.04
Polymeric Mechanical Amplifiers of Tumor Cell Mechanotransduction and Cell Death

Michael J. Mitchell 1 Robert Langer 1

1MIT Cambridge United States

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4:45 AM - K5.05
Single-Cell Cytokine Profiling Microchip for Measuring Dysregulated Cellular Function in Hematopoietic Malignancy

Minsuk Kwak 1 Maria Kleppe 2 Ross L Levine 2 3 Rong Fan 1 4

1Yale Univ New Haven United States2Memorial Sloan-Kettering Cancer Center New York United States3Memorial Sloan-Kettering Cancer Center New York United States4Yale Comprehensive Cancer Center New Haven United States

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5:00 AM - K5.07
Layer-by-Layer Nanoparticles for Delivery of Second Window Near-Infrared Probes in Vivo

Li Gu 1 Xiangnan Dang 1 Santiago Correa Echavarria 1 Angela M. Belcher 1 Paula T. Hammond 1

1MIT Cambridge United States

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K4/L4: Joint Session: Nanotechnology Enabled Clinical Advances
Session Chairs
Rong Fan
Robert Sinclair
Vinayak Dravid
Tuesday AM, December 01, 2015
Hynes, Level 3, Ballroom A

9:30 AM - *K4.01/L4.01
Cancer Nanotechnology - Current Challenges and Future Opportunities - View from the NCI Alliance for Nanotechnology in Cancer

Piotr Grodzinski 1

1National Cancer Institute/NIH Bethesda United States

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10:00 AM - *K4.02/L4.02
New Technologies and Applications for Exosome Analysis

Ralph Weissleder 1

1Massachusetts General Hospital Boston United States

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10:30 AM - *K4.03/L4.03
Advanced RNA Analysis in Live Cells via ldquo;Stickyflarerdquo; Nanoconjugates

Chad A. Mirkin 1

1Northwestern Univ Evanston United States

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11:00 AM -
BREAK

11:30 AM - *K4.04/L4.04
Nanotechnologies for Assessing Single CTC Molecular Profiles in the Diagnosis and Treatment of Lung Cancer

Shan X. Wang 1

1Stanford Univ Stanford United States

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12:00 PM - *K4.05/L4.05
Capturing Multiple Levels of Biological Information from Single Cells for Fundamental and Clinical Applications

James R. Heath 1

1California Inst of Technology Pasadena United States

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12:30 PM - K4.06/L4.06
Ultrasound Sensitive Nanoparticle Aggregates for Targeted Therapy in Breast Cancer

Anne-Laure Papa 1 Netanel Korin 1 Akiko Mammoto 2 Mathumai Kanapathipillai 1 Tadanori Mammoto 2 Oktay Uzun 1 Christopher Johnson 1 Deen Bhatta 1 Donald Elliot Ingber 1 2 3

1Wyss Institute for Biologically Inspired Engineering at Harvard University Boston United States2Boston Children's Hospital Boston United States3Harvard University Cambridge United States

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12:45 PM - K4.07/L4.07
Near Infrared Fluorescent Self-Assembled Nanoparticles for Image-Guided Surgery

Sneha Kelkar 2 Tanner Hill 1 William Payne 2 Aaron Mohs 1 3

1University of Nebraska Medical Center Omaha United States2Wake Forest University Health Sciences Winston-Salem United States3University of Nebraska Medical Center Omaha United States

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2015-12-02   Show All Abstracts

Symposium Organizers

Tony Dickherber, National Cancer Institute
Rong Fan, Yale University
Sharon Gerecht, Johns Hopkins University
Sebastian Maerkl, Ecole Polytechnique Federale de Lausanne
Miqin Zhang, University of Washington
K7: Nanotechnology Enabled Clinical Advances
Session Chairs
Tony Dickherber
Rong Fan
Wednesday PM, December 02, 2015
Hynes, Level 3, Room 301

2:30 AM - *K7.01
Highly Penetrative, Drug-Loaded Nanocarriers for Treatment of Brain Tumors

W. Mark Saltzman 1

1Yale University New Haven United States

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3:00 AM - *K7.02
Engineered Devices to Treat Invasive Brain Tumors

Ravi Bellamkonda 1

1Georgia Tech College of Engineering amp; Emory School of Medicine Atlanta United States

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3:30 AM -
BREAK

4:30 AM - K7.03
Solid-State Magnetic Resonance Imaging Contrast Agents for Quantitative pH Monitoring

Gregory James Ekchian 1 Vincent Liu 1 Michael Cima 1

1Massachusetts Institute of Technology Cambridge United States

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4:45 AM - K7.04
Deep and High-Resolution 3D Tracking of Single Particles Using Nonlinear and Multiplexed Illumination (TSUNAMI)

Evan Perillo 1 Yen-Liang Liu 1 Khang Huynh 1 Cong Liu 1 Chao-Kai Chou 2 Mien-Chie Hung 2 Hsin-Chih Yeh 1 Andrew K Dunn 1

1University of Texas at Austin Austin United States2The University of Texas MD Anderson Cancer Center Houston United States

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5:00 AM - K7.05
High-Content Imaging of Single Cell Heterogeneity on Wrinkled 2.5D Graphene Nanotopographies

Susan E Leggett 1 Zhongying Wang 1 Daniel Tonderys 1 Evelyn Kendall Williams 1 Mehrdad Kiani 1 Robert H Hurt 1 Ian Yan Wong 1

1Brown Univ Providence United States

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5:15 AM - K7.06
Shortwave-Infrared Fluorescence Probes towards Non-Invasive Imaging and Surgical Guidance of Sub-Millimeter Tumors

Debadyuti Ghosh 1 Alexander Bagley 3 Young Jeong Na 3 Michael Birrer 3 Sangeeta Bhatia 2 Angela M. Belcher 2

1The University of Texas at Austin Austin United States2MIT Cambridge United States3Harvard Medical School/MGH Cambridge United States

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5:30 AM - K7.07
Second Window near Infrared Fluorescent Imaging for Deep Tissue and Animal Imaging

Xiangnan Dang 1 Neelkanth M Bardhan 1 Angela M. Belcher 1

1MIT Cambridge United States

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5:45 AM - K7.08
[64Cu]Cu Clusters for Targeting Orthotopic Lung Tumors via Positron Emission Tomography Imaging

Xueyun Gao 1

1Chinese Academy of Science Beijing China

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K8: Poster Session II: Advancing Clinical Capabilities against Cancer
Session Chairs
Rong Fan
Sharon Gerecht
Wednesday PM, December 02, 2015
Hynes, Level 1, Hall B

9:00 AM - K8.01
Staged Tumorigenesis-Mimicking Matrices to Increase Chemoresistance for Anticancer Drug Screening

Takashi Hoshiba 1 2 Masaru Tanaka 3

1Yamagata University Yonezawa Japan2National Institute for Materials Science Tsukuba Japan3Kyushu University Fukuoka Japan

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9:00 AM - K8.02
Quantifying the Growth Dynamics of Drug Sensitive and Resistant Lung Cancer Cells Using an Impedance Measurement Microchip

Jonathan J Chen 1 William Pao 2 Franziska Michor 3 4 Rong Fan 1

1Yale University New Haven United States2Vanderbilt University Nashville United States3Dana-Farber Cancer Institute Boston United States4Harvard T.H. Chan School of Public Health Boston United States

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9:00 AM - K8.03
Transient Nanoparticle Energy Transduction as a Platform for Intracellular Drug Delivery

Stefany Y. Holguin 1 Michael Gray 2 Mark R. Prausnitz 3 Naresh N. Thadhani 1

1Georgia Institute of Technology Atlanta United States2Georgia Institute of Technology Atlanta United States3Georgia Institute of Technology Atlanta United States

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9:00 AM - K8.04
The Effect of Red Selenium Nanoparticles on Decreasing Head and Neck Squamous Cell Carcinoma

Christopher Edward Hassan 1 Thomas Webster 1

1Northeastern Univ Boston United States

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9:00 AM - K8.05
Photothermal Heating Efficiency of Multifunctional Flame-Made SiO2 Coated Au/Fe2O3 Nanoaggregates iia In Situ Magnetic Resonance Imaging

Fabian Starsich 2 Moritz Wurnig 1 Andreas Boss 1 Sotiris E. Pratsinis 2

1University Hospital Zurich Zurich Switzerland2ETH Zurich Zurich Switzerland

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9:00 AM - K8.06
Bimodal Magnetic Nanobeads for MRI/PET Cancer Diagnostics

Isabel Gessner 1 Markus Schuetz 1 Laura Wortmann 1 Shaista Ilyas 1 Shifaa Siribbal 1 Thomas Fischer 1 Sanjay Mathur 1

1University of Cologne Cologne Germany

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9:00 AM - K8.07
Supramolecular Hydrogel Based Peptides for Cancer Therapy

Chengbiao Yang 1 Zhimou Yang 1

1Nankai University Tianjin China

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K6: Cancer Modeling
Session Chairs
Sharon Gerecht
Miqin Zhang
Wednesday AM, December 02, 2015
Hynes, Level 3, Room 301

9:30 AM - *K6.01
Building a ldquo;Body-on-a-Chiprdquo; for Development

Michael L Shuler 1 2

1Cornell University Ithaca United States2Hesperos, Inc. Ithaca United States

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10:00 AM - *K6.02
Bioengineered Models of Human Bone Tumors

Gordana Vunjak-Novakovic 1 2 Aranzazu Villasante 1 Allessandro Marturano 1

1Columbia University New York United States2Columbia University New York United States

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10:30 AM - *K6.03
3D In Vitro Models of Tumor Cell Extravasation

Roger D Kamm 1 Michelle B Chen 1

1M.I.T. Cambridge United States

Show Abstract

11:00 AM -
BREAK

11:30 AM - *K6.04
Single Cell Heterogeneity and the Epithelial-Mesenchymal Transition in Engineered Microenvironments

Ian Yan Wong 1

1Brown Univ Providence United States

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12:00 PM - K6.05
A Novel Scaffold for 3D Tumour Cell Culture

C. J. Luo 1 Ahmed A. Ahmed 2 Sandra Perez-Garrido 2 Connor R. Browse 2 Simeon Stoyanov 3 Pete Geisen 4 Miles Wright 4 Ivan Gout 2 Stoyan K. Smoukov 1

1University of Cambridge Cambridge United Kingdom2University College London London United Kingdom3University College London London United Kingdom4Xanofi Raleigh United States

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12:15 PM - K6.06
Size-Controlled Three-Dimensional Microtumors Mimic Hallmarks of Breast Cancer Progression

Manjulata Singh 1 Shilpaa Mukundan 1 Steffi Oesterriech 4 Shilpa Sant 1 2 3

1University of Pittsburgh School of Pharmacy Pittsburgh United States2University of Pittsburgh School of Engineering Pittsburgh United States3McGowan Institute for Regenerative Medicine Pittsburgh United States4University of Pittsburgh Cancer Institute Pittsburgh United States

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12:30 PM - K6.07
Formation of 3D Tight Junction Tumoroids on Biomimetic Nanoclay Scaffolds

Kalpana Katti 1 MD Shahajahan Molla 1 Dinesh R. Katti 1

1North Dakota State Univ Fargo United States

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12:45 PM - K6.08
Rapid 3D Extrusion of Synthetic Tumor Microenvironment

Joshua Micah Grolman 1 Douglas Zhang 1 Andrew M Smith 2 Jeffrey S Moore 1 3 Kristopher Kilian 1 2

1University of Illinois at Urbana-Champaign Urbana United States2University of Illinois at Urbana-Champaign Urbana United States3University of Illinois at Urbana-Champaign Urbana United States

Show Abstract

2015-12-03   Show All Abstracts

Symposium Organizers

Tony Dickherber, National Cancer Institute
Rong Fan, Yale University
Sharon Gerecht, Johns Hopkins University
Sebastian Maerkl, Ecole Polytechnique Federale de Lausanne
Miqin Zhang, University of Washington
K10: Novel Materialsmdash;Enabled Cancer Treatment Strategies
Session Chairs
Sharon Gerecht
Tony Dickherber
Thursday PM, December 03, 2015
Hynes, Level 3, Room 301

2:30 AM - K10.01
Reprogramming Tumor Associated Macrophages by Engineering Polymer Surface Properties

Kaitlin Bratlie 1 2 3

1Iowa State Univ Ames United States2Iowa State University Ames United States3Ames Laboratory Ames United States

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2:45 AM - K10.02
Novel Approach to Enhance Bioavailability of Organic Small Molecule Medicines by Deposition from Vapor Phase

Olga Shalev 1 Shreya Raghavan 1 J. Maxwell Mazzara 1 Nancy Senabulya 1 Christopher Rockwell 1 Nicholas Simopoulos 1 Geeta Mehta 1 Anna Shwendeman 1 Roy Clarke 1 Max Shtein 1

1University of Michigan, Ann-Arbor Ann Arbor United States

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3:00 AM - K10.03
Silk-Collagen Hydrogels as Designer 3D Microenvironments for the Epithelial-Mesenchymal Transition

Thomas Valentin 1 Susan E Leggett 1 Hayley D McClintock 1 Ian Yan Wong 1

1Brown Univ Providence United States

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3:15 AM - K10.04
Efficacy of Paclitaxel Impacted by Both Three Dimensional Culture and Tumor Macrostructure

Kristie Mercedes Tevis 1 Daniel Reynolds 1 Muhammad Zaman 1 Mark W Grinstaff 1 2

1Boston Univ Boston United States2Boston University Boston United States

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3:30 AM - K10.05
Re-Examining the Size/Charge Paradigm and Other Misconceptions in Nanocarrier-Based Delivery for Cancer

Jason Townson 3 Yu-Shen Lin 3 Natalie Adolphi 4 Carlee Ashley 1 Paul N. Durfee 2 Kimberly S. Butler 2 Hon S. Leong 5 6 C. Jeffrey Brinker 1 2

1Sandia National Labs Albuquerque United States2University of New Mexico Albuquerque United States3Oncothyreon, Inc. Seattle United States4University of New Mexico Albuquerque United States5Schulich School of Medicine and Dentistry London Canada6Schulich School of Medicine and Dentistry London Canada

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