Meetings & Events

2012 MRS Spring Meeting Logo

2012 MRS Spring Meeting & Exhibit

April 9-13, 2012 | San Francisco
Meeting Chairs: Lara A. Estroff, Jun Liu, Kornelius Nielsch, Kazumi Wada

Symposium PP : Manipulating Cellular Microenvironments

2012-04-10   Show All Abstracts

Symposium Organizers

Michael Schwartz, University of Wisconsin-Madison
Todd C. McDevitt, Georgia Institute of Technology
Matthias P. Lutolf, EPFL-SV-IBI-LSCB
Joel P. Schneider, National Cancer Institute-Frederick

Symposium Support

Glycosan Biosystems, Inc. A Division of Orthocyte Corp.
National Science Foundation

PP2: Engineering Platforms for Dynamic or Spatial Control Over the Microenvironment
Session Chairs
Michael Schwartz
Tuesday PM, April 10, 2012
Marriott, Yerba Buena, Salons 10-11

2:30 AM - *PP2.1
3-D Biofabrication for Development of Cellular Systems

Piyush Bajaj 1 2 Vincent Chan 1 2 Jae H Jeong 4 5 Pinar Zorlutuna 1 2 Chaenyung Cha 4 Hyun J Kong 4 2 5 Rashid Bashir 3 1 2

1UIUC Urbana USA2UIUC Urbana USA3UIUC Urbana USA4UIUC Urbana USA5UIUC Urbana USA

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3:00 AM - PP2.2
Microfluidic Cell Culture Chambers with Nanoporous Walls for Chemical Communication

Zhifei Ge 1 Peter R Girguis 2 Cullen R Buie 1

1Massachusetts Institute of Technology Cambridge USA2Harvard University Cambridge USA

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3:15 AM - PP2.3
Deconstructing the Effects of Matrix Stiffness and Confinement on Cell Migration

Amit Pathak 1 Sanjay Kumar 1

1University of California, Berkeley Berkeley USA

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3:30 AM - PP2.4
Flipping the Switch: Engineering Cell-instructive Microenvironments with Photo-activatable ``Caged'' Peptides

Daniel L Alge 2 Kristi S Anseth 1 2

1University of Colorado Boulder USA2Howard Hughes Medical Institute Boulder USA

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3:45 AM -
Break

4:15 AM - *PP2.5
Dynamic Cell Niches through Bioorthogonal Photochemical Reactions

Cole DeForest 1 Mark Tibbitt 1 Kristi Anseth 1 2

1University of Colorado Boulder USA2Howard Hughes Medical Institute Boulder USA

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4:45 AM - PP2.6
Engineering Stem Cell Microenvironment with Independently Tunable Biochemical and Mechanical Properties

Xinming Tong 1 Fan Yang 1 2

1Stanford University Stanford USA2Stanford University Stanford USA

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5:00 AM - PP2.7
Manipulating Thiol-ene Hydrogel Degradation for Controlling 3D Cell Morphogenesis

Han Shih 1 Chien-Chi Lin 1

1Indiana-University Purdue-University Indianapolis Indianapolis USA

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5:15 AM - PP2.8
Influence of a Zwitterionic Polymer Brush on Stem Cell Morphology and Function

Aftin Monique Ross 1 Thomas Eyster 2 Luis G Villa-Diaz 3 Jonathan Oh 4 Priya Moni 4 Domenic Kratzer 5 Paul H Kresbach 1 3 Joerg Lahann 1 2 4

1Univ Michigan Ann Arbor USA2University of Michigan Ann Arbor USA3University of Michigan Ann Arbor USA4University of Michigan Ann Arbor USA5Karlsruhe Institute of Technology Karlsruhe Germany

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5:30 AM - PP2.9
Nano-bottlebrush Electrospun Fibres for Investigation of Cell-substrate Interactions

Andrew E Rodda 1 2 3 David R Nisbet 4 1 Laurence Meagher 2 3 Kevin E Healy 5 John S Forsythe 1 3

1Monash University Clayton Australia2CSIRO Clayton Australia3Cooperative Research Centre for Polymers Notting Hill Australia4The Australian National University Canberra Australia5University of California Berkeley USA

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5:45 AM - PP2.10
Elastic Conductive Polymer Nanofiber Scaffolds for Tissue Regeneration

Craig A. Milroy 1 Christopher Ellison 1 Christine E Schmidt 1 2

1University of Texas, Austin Austin USA2University of Texas, Austin Austin USA

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PP3: Poster Session: Manipulating Cellular Micronevirnoments
Session Chairs
Joel Schneider
Tuesday PM, April 10, 2012
Moscone West, Level 1, Exhibit Hall

6:00 AM - PP3.1
Influence of Hydrogel Matrix Properties on Proliferation of Pancreatic beta;-cells in 3D

Asad Raza 1 Chien-Chi Lin 1

1Indiana University Purdue Univeristy Indianapolis Indianapolis USA

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6:00 AM - PP3.10
Fabrication of Alginate Microstrands for 3D Mimicking of the Stem Cell Microenvironment

Andrea Unser 1 Bridget Mooney 1 Christopher Bowman 1 Dennis Pu 1 Nurazhani Abdul Raof 1 Magnus Bergkvist 1 Yubing Xie 1

1University at Albany College of Nanoscale Science and Engineering Albany USA

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6:00 AM - PP3.11
Tailoring Supramolecular Interactions to Control Cell Response: From Viability to Proliferation to Morphogenesis

Christina Jane Newcomb 1 Shantanu Sur 2 Samuel I Stupp 1 2 3

1Northwestern University Evanston USA2Northwestern University Chicago USA3Northwestern University Evanston USA

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6:00 AM - PP3.12
Natural Polymers Based Scaffolds for Chondrogenic Differentiation of Human Mesenchymal Stem Cells

Nandita Singh 1 Sameer S Rahatekar 2 Krzysztof Koziol 3 Avinash Patil 4 Sky Ng 1 Stephen Mann 4 Anthony Hollander 1 Wael Kafienah 1

1University of Bristol Bristol United Kingdom2University of Bristol Bristol United Kingdom3University of Cambridge Cambridge United Kingdom4University of Bristol Bristol United Kingdom

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6:00 AM - PP3.13
Identification of Neural Crest-like Synovial Stem Cells

Fang Huang 1 Zhenyu Tang 1 Song Li 1

1University of California, Berkeley Berkeley USA

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6:00 AM - PP3.15
Direct Printing of 3D Microscaffolds for the Study of Interstitial Cell Migration

Julian Roman Schneider 1 Patrick Galliker 1 Tobias Bachmann 1 Aldo Ferrari 1 Manish K Tiwari 1 Dimos Poulikakos 1

1ETH Zurich Zurich Switzerland

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6:00 AM - PP3.17
Cancer Adaptation to Drug Gradient in Microfluidic Microenvironments

Amy Wu 1 3 Guillaume Lambert 2 3 Robert H Austin 2 3 James C Sturm 1 3 Chira Chen-Tanyolac 4 Thea D Tlsty 4

1Princeton University Princeton USA2Princeton University Princeton USA3Princeton Institute for the Science and Technology of Materials (PRISM) Princeton USA4University of California, San Francisco San Francisco USA

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6:00 AM - PP3.19
Cellulose Nanowhiskers: Nanoscale Cues for Directing Skeletal Muscle Myogenesis

James M Dugan 1 Julie E Gough 1 Stephen J Eichhorn 2

1The University of Manchester Manchester United Kingdom2University of Exeter Exeter United Kingdom

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6:00 AM - PP3.2
Engineering Intestinal Microenvironments: Progress towards a New Preclinical Drug Screening Platform

Rebecca Snyder 1 James Su 2 Calvin Kuo 3 Sarah Heilshorn 2

1Stanford University Stanford USA2Stanford University Stanford USA3Stanford University Stanford USA

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6:00 AM - PP3.20
A Completely Synthetic, Micro-patterned Culture Surface for Human Embryonic Stem Cells

Felicia L Svedlund 1 Colleen Courtney 2 Elizabeth Irwin 1 Albert Lin 1 Kevin E Healy 1

1UC Berkeley Berkeley USA2UMBC Baltimore USA

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6:00 AM - PP3.21
Characterization of a Functionalized Nanoneedle Array for Protein Detection as a High Throughput Biomarker Discovery Platform

Rahim Esfandyarpour 1 Hesaam Esfandyarpour 1 Mehdi Javanmard 1 Ronald W Davis 1

1Stanford University Stanford USA

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6:00 AM - PP3.23
Photoswitchable block copolymer for micropatterning different cell types

Kyu-Shik Mun 1 Ross Andrews 1 Carlos C Co 1 Chia-Chi Ho 1

1University of Cincinnati Cincinnati USA

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6:00 AM - PP3.4
Engineering Poly(ethylene glycol) Hydrogel Microenvironments to Promote Mesenchymal Stem Cell Proliferation

Michael Hoffman 1 2 Danielle Benoit 1 2 3

1University of Rochester Rochester USA2University of Rochester Medical Center Rochester USA3University of Rochester Rochester USA

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6:00 AM - PP3.5
Photo-sensitive Biocompatible Hydrogels Structuring Extracellular Environments by Two Photon Polymerisation

Jurgen Stampfl 1 Jan Torgersen 1 Aleksandr Ovsianikov 1 Xiaohua Qin 2 Zhiquan Li 2 Vladimir Mironov 1 Robert Liska 2

1TU Wien Vienna Austria2TU Wien Vienna Austria

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6:00 AM - PP3.6
Dual-crosslinked Alginate for Spatial Control of Hydrogel Material Properties

Julia E. Samorezov 1 Eben Alsberg 1 2

1Case Western Reserve University Cleveland USA2Case Western Reserve University Cleveland USA

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6:00 AM - PP3.7
Nanotopography-based Gene Delivery and ECM Protein Patterns for Neuro-differentiation of Stem Cells

Aniruddh Solanki 1 Shreyas Shah 1 Ki-Bum Lee 1

1Rutgers University Piscataway USA

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6:00 AM - PP3.9
Micropatterning and Covalent Immobilization of Multiple Bioactive Molecules for Regenerative Medicine Applications

Pascal Jonkheijm 1

1Mesa Institute for Nanotechnology Enschede Netherlands

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PP1: Engineering Approaches for Deconstructing the Complexity of the Microenvironment
Session Chairs
Matthias Lutolf
Tuesday AM, April 10, 2012
Marriott, Yerba Buena, Salons 10-11

9:30 AM - *PP1.1
Bioengineered Niches to Control Stem Cell Fate and Function

Helen M. Blau 1

1Stanford University Stanford USA

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10:00 AM - *PP1.2
Engineering 3D Microenvironments to Promote Vascular Sprouting Morphogenesis

Sarah C Heilshorn 1

1Stanford University Stanford USA

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10:30 AM - PP1.3
Droplet-based Microfluidic Generation of Microcarriers for Stem Cell Manipulation

Simone Allazetta 1 Matthias P Lutolf 1

1Ecole Polytechnique Federale de Lausanne Lausanne Switzerland

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10:45 AM - PP1.4
Screening for Defined Microenvironments that Support Breast Cancer Cell Growth Using an Automated Microfluidic Platform

Sara I. Montanez-Sauri 1 3 Kyung E Sung 2 3 Erwin Berthier 2 3 David J Beebe 2 3

1University of Wisconsin-Madison Madison USA2University of Wisconsin-Madison Madison USA3Wisconsin Institutes for Medical Research Madison USA

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11:00 AM -
Break

11:30 AM - *PP1.5
Engineering the Interface: From Stem Cells to Smart Biomaterials

Shyni Varghese 1

1UC San Diego La Jolla USA

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12:00 PM - *PP1.6
Microfluidic Tools for Controlling and Imaging Cell, Particles, and Embryos

Hang Lu 1

1Georgia Institute of Technology Atlanta USA

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12:30 PM - PP1.7
Three-dimensional Organotypic Tissue Arrays for Quantitative Analysis of Morphogenesis

Nikolce Gjorevski 1 Amira L Pavlovich 1 Sriram Manivannan 1 KangAe Lee 1 2 Celeste M Nelson 1 2

1Princeton University Princeton USA2Princeton University Princeton USA

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12:45 PM - PP1.8
Probing Tumor Cell Migration, Growth, and Invasion Using a Synthetic 3D Extracellular Matrix Based on "thiol-ene" Photopolymerization to Control the Microenvironment

Michael P. Schwartz 1 Samir P Singh 2 Justin Y Lee 2 Justin T Koepsel 1 Muhammad H Zaman 4 Natalie G Ahn 3 Kristi S Anseth 2 William L Murphy 1

1University of Wisconsin-Madison Madison USA2University of Colorado-Boulder Boulder USA3University of Colorado-Boulder Boulder USA4Boston University Boston USA

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2012-04-11   Show All Abstracts

Symposium Organizers

Michael Schwartz, University of Wisconsin-Madison
Todd C. McDevitt, Georgia Institute of Technology
Matthias P. Lutolf, EPFL-SV-IBI-LSCB
Joel P. Schneider, National Cancer Institute-Frederick

Symposium Support

Glycosan Biosystems, Inc. A Division of Orthocyte Corp.
National Science Foundation

PP5/QQ5: Joint Session: Mechanobiology of the Extracellular Matrix II
Session Chairs
Joel Schneider
Wednesday PM, April 11, 2012
Marriott, Yerba Buena, Salons 10-11

2:30 AM - *PP5.1/QQ5.1
Biomaterial Tools in Regenerative Medicine

Jennifer Elisseeff 1

1Johns Hopkins University Baltimore USA

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3:00 AM - *PP5.2/QQ5.2
Engineering Three-dimensional Stem Cell Microenvironment Using a Combinatorial Approach

Fan Yang 1

1Stanford University Stanford USA

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3:30 AM - PP5.3/QQ5.3
The Impact of Controlled Biophysical and Biochemical Cues on HCEC Cell Behavior

Sara Liliensiek 1 Bernardo Yanez-Soto 1 Elizabeth J Tocce 1 Michelle J Wilson 1 Adam H Broderick 1 Christopher J Murphy 2 3 David M Lynn 1 Paul F Nealey 1

1University of Wisconsin Madison USA2University of California, Davis Davis USA3University of California, Davis Davis USA

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3:45 AM - PP5.4/QQ5.4
Controlling Complex Cell Phenotypic ``Switching'' through Orthogonal Biochemical and Biophysical ECM Cues

Marilyn C Markowski 1 Ashley C Brown 1 Thomas H. Barker 1 2

1Georgia Institute of Technology Atlanta USA2Georgia Institute of Technology Atlanta USA

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4:00 AM -
Break

4:30 AM - *PP5.5/QQ5.5
Quantifying Tumor Cell Fate in 3D Environments

Muhammad H Zaman 1

1Boston University Boston USA

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5:00 AM - *PP5.6/QQ5.6
Traction Mechanics of Directed Cell Motility of Immune Cells

Daniel Hammer 1 Christopher Hunter 2 Brendon Ricart 1 Beena John 2

1U. Pennsylvania Philadelphia USA2University of Pennsylvania Philadelphia USA

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5:30 AM - PP5.7/QQ5.7
Deconstructing Biophysical and Biochemical Influences on Tumor Cell Migration Mechanisms

Samir P. Singh 1 Michael P Schwartz 3 Justin Y Lee 1 Kristi S Anseth 1 2

1University of Colorado, Boulder Boulder USA2Howard Hughes Medical Institute Boulder USA3University of Wisconsin, Madison Madison USA

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5:45 AM - PP5.8/QQ5.8
Elucidating the Mechanisms of Glioma Invasion Using Brain-mimetic Hyaluronic Acid Matrices

Badriprasad Ananthanarayanan 1 Yushan Kim 1 Sanjay Kumar 1

1Univ California Berkeley Berkeley USA

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PP4/QQ4: Joint Session: Mechanobiology of the Extracellular Matrix I
Session Chairs
Delphine Gourdon
Wednesday AM, April 11, 2012
Marriott, Yerba Buena, Salons 10-11

9:15 AM - *PP4.1/QQ4.1
Stiffness, Tension, and Fibronectin Matrix Assembly

Jean Schwarzbauer 1

1Princeton University Princeton USA

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9:45 AM - *PP4.2/QQ4.2
Diblock Copolymer Foams with Adhesive Nano-domains Promote Stem Cell Differentiation

Somyot Chirasatitsin 1 Priyalakshmi Viwanathan 2 Giuseppe Battaglia 2 Adam Engler 1

1UC San Diego La Jolla USA2University of Sheffield Sheffield United Kingdom

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10:15 AM - PP4.3/QQ4.3
Detecting Force-induced Structural States of Fibronectin In vivo with Novel Molecular Probes

Lizhi Cao 1 Vince F Fiore 1 Patrick Strane 1 Harry Bermudez 2 Thomas H. Barker 1 3

1Georgia Institute of Technology Atlanta USA2University of Massachusetts Amherst Amherst USA3Georgia Institute of Technology Atlanta USA

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10:30 AM - PP4.4/QQ4.4
Multiscale Approach to Link Fibronectinrsquo;s Single Molecule Mechanical and Bulk Material Properties

Mark Bradshaw 1 Michael L. Smith 1

1Boston University Boston USA

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10:45 AM - PP4.5/QQ4.5
Fluorescence Resonance Energy Transfer (FRET) to Probe Fibronectin Conformation and Strain in Tumors In vitro

Karin Wang 1 Roberto C Andresen Eguiluz 2 Bo Ri Seo 1 Claudia Fischbach 1 Delphine Gourdon 2

1Cornell University Ithaca USA2Cornell University Ithaca USA

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11:00 AM -
BREAK

11:30 AM - *PP4.6/QQ4.6
Adipose Stem Cells as Physicochemical Regulators of Breast Tumorigenesis

Emily M Chandler 1 Bo Ri Seo 1 Karin Wang 1 Roberto Andresen-Eguiluz 2 Joseph P Califano 1 Christine J Yoon 1 James X Wang 1 Mark R Buckley 3 Itai Cohen 3 Cynthia A Reinhart-King 1 Delphine Gourdon 1 Claudia Fischbach 1

1Cornell University Ithaca USA2Cornell University Ithaca USA3Cornell University Ithaca USA

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12:00 PM - PP4.7/QQ4.7
Computational Analysis of Cancer-cell Invasion Based on Multi-physics Analysis Technology

Dongchoul Kim 1 Linan Zhang 1

1Sogang University Seoul Republic of Korea

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12:15 PM - PP4.8/QQ4.8
Breast Tumor Soluble Factors Stiffen Extracellular Matrix

Roberto C Andresen Eguiluz 1 Karin Wang 2 Delphine Gourdon 1

1Cornell University Ithaca USA2Cornell Univeristy Ithaca USA

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12:30 PM - PP4.9/QQ4.9
Obesity-Associated Adipose Stromal Cells as Physicochemical Modulators of Breast Tumorigenesis

Bo Ri Seo 1 Jacqueline Gonzalez 2 Karin Wang 1 Sunish Mohanan 3 Haibo Sha 4 Liu Yang 4 Priya Bhardwaj 5 Linda T Vahdat 5 Andrew J Dannenberg 5 Ling Qi 6 Delphine Gourdon 7 Claudia Fischbach 1

1Cornell University Ithaca USA2Cornell University Ithaca USA3Cornell University Ithaca USA4Cornell University Ithaca USA5Cornell University New York USA6Cornell University Ithaca USA7Cornell University Ithaca USA

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12:45 PM - PP4.10/QQ4.10
Elastic Discontinuities in Tissues and at Interfaces Can Impair Joint Function

Sunita P. Ho 1 Jonathan M Hurng 1 Michael P Kurylo 1 Jeremy D Lin 1 Grayson W Marshall 1 Samuel Webb 2 Joy H Andrews 2 Piero Pianetta 2

1UCSF San Francisco USA2SLAC Menlo Park USA

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2012-04-12   Show All Abstracts

Symposium Organizers

Michael Schwartz, University of Wisconsin-Madison
Todd C. McDevitt, Georgia Institute of Technology
Matthias P. Lutolf, EPFL-SV-IBI-LSCB
Joel P. Schneider, National Cancer Institute-Frederick

Symposium Support

Glycosan Biosystems, Inc. A Division of Orthocyte Corp.
National Science Foundation

PP7: Extracellular Matrix Inspired Strategies for Designing Biomaterials and Guiding Cell Function
Session Chairs
Matthias Lutolf
Thursday PM, April 12, 2012
Marriott, Yerba Buena, Salons 10-11

2:30 AM - *PP7.1
Learning from the Extracellular Matrix to Guide Cardiovascular Tissue Regeneration and Elucidate Disease Etiologies

Kristyn Simcha Masters 1

1University of Wisconsin Madison USA

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3:00 AM - *PP7.2
Collagen-mimetic Hydrogels and MSC Fate Decisions

Mariah S Hahn 1 3 Silvia Becerra-Bayona 3 Viviana Guiza 1 Brooke Russell 2 Magnus Hook 2

1Texas Aamp;M University College Station USA2Texas Aamp;M Health Science Center Houston USA3Texas Aamp;M University College Station USA

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3:30 AM - PP7.3
Defined Extracellular Microenvironment for Controlling 3D Morphogenesis of Pancreatic Epithelial Cells

Asad Raza 1 Chien-Chi Lin 1

1Indiana University-Purdue University at Indianapolis Indianapolis USA

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3:45 AM - PP7.4
Dynamic Tissue Engineering Scaffolds with Stimuli-responsive Macroporosity Formation

Li-Hsin Han 1 Stephanie Yu 2 Fan Yang 1 3

1Stanford University Stanford USA2Stanford University Stanford USA3Stanford University Stanford USA

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4:00 AM -
Break

4:30 AM - *PP7.5
Maleimide Cross-linked Biofunctional Poly(ethylene glycol) Hydrogels for Enhanced Cell Engraftment and Tissue Repair

Andres J Garcia 1

1Georgia Institute of Technology Atlanta USA

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5:00 AM - PP7.6
An In vitro Model of Endometriosis

Kathryn Pollock 1 Pamela Kreeger 1

1UW-Madison Madison USA

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5:15 AM - PP7.7
Glycosaminoglycan-based Functional Gradients for Cellular Response

Lesley W Chow 1 Cristina Gentilini 1 Seth D McCullen 1 Molly M Stevens 1 2

1Imperial College London London United Kingdom2Imperial College London London United Kingdom

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5:30 AM - PP7.8
Synthetic Hydrogels with Controlled Epitope Spacing for Selective Integrin Activation

Eugene Thomas Pashuck 1 Benoit Duchet 2 Molly M Stevens 1 2

1Imperial College London London United Kingdom2Imperial College London London United Kingdom

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5:45 AM - PP7.9
Hybrid Self-assemblies of Synthetic Peptides and Expressed Proteins with Precise Compositional Control

Gregory Hudalla 1 Tao Sun 1 Joshua Gasiorowski 1 Joel Collier 1

1University of Chicago Chicago USA

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PP6: Biomedical Engineering Strategies for Therapeutic Applications
Session Chairs
Matthias Lutolf
Thursday AM, April 12, 2012
Marriott, Yerba Buena, Salons 10-11

9:30 AM - *PP6.1
Clinical Biomaterials for Lab and Clinic: From Bench to Business

Glenn Prestwich 1

1University of Utah Salt Lake City USA

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10:00 AM - *PP6.2
Injectable Temperature Responsive Hydrogels Derived from Decellularized Matrices

Karen L. Christman 1

1UC San Diego La Jolla USA

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10:30 AM - PP6.3
Design of Peptide-based Hydrogels for the Direct Encapsulation and Syringe Delivery of Primary Chondrocytes

Joel Schneider 1

1National Cancer Institute Frederick USA

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10:45 AM - PP6.4
A 3D Protein-Engineered Matrix for Stem Cell Differentiation and Transplantation

Andreina Parisi-Amon 1 Widya Mulyasasmita 1 Cindy Chung 2 3 Cheryl Wong Po Foo 2 Michael T Longaker 4 Sarah C Heilshorn 2

1Stanford University Stanford USA2Stanford University Stanford USA3Stanford University Stanford USA4Stanford University School of Medicine Stanford USA

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11:00 AM -
Break

11:30 AM - *PP6.5
Exploiting siRNA Delivery to Mesenchymal Stem Cells to Engineer Musculoskeletal Tissues

Danielle SW Benoit 1 2 3 Molly E Boutin 1 4 Daniel Reynolds 1

1University of Rochester Rochester USA2University of Rochester Rochester USA3University of Rochester Rochester USA4Brown University Providence USA

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