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Symposium SB09-Bioelectricity and Recapitulation of 3D Environment in Microbial and Tissue Engineering

Spurred by decades of success with pacemakers and cochlear implants, and by advances in miniaturized technology, interest is surging in electroceuticals that stimulate nerves to treat disease. This mainly encompasses technological advancements in the field of cardiac, cochlear, retinal, central nervous system and peripheral nervous system implants. However, implementing bioelectronics as a primary or complementary treatment for cancer has also garnered momentum in the recent years.

The evolving momentum is due to the modest knowledge in basic biological functions of cancer, at a cellular level. This lack of in depth understanding of its physiology significantly limits the development of new, targeted and more effective treatment strategies. The emergence of innovative composite materials, comprising different morphologies and designs are of utmost importance to interface, probe, decode, and modulate cancer cells signalling in for example 3D solid tumour models, such as spheroids and organoids - for recreating tumorigenesis in vitro.

Bioelectricity seeks to become an important biophysical indicator beyond cancer physiology. Biomaterials may be applied to monitor and/or modulate communication within other electroactive microorganisms such as bacteria and algae, with the aim of developing new microelectronic technologies, eventually AI-assisted, capable of recreating and controlling metabolic and signalling pathways on-a-chip.

The scope of this interdisciplinary symposium is to deliver a setting for discussion on the field of bioelectricity in living microbe-inspired materials. The symposium englobes and seeks to bridge the disciplines of materials science, physics, electronics, bioinformatics, and biology to enable the development of next-generation of biomaterials and devices.




Topics will include:

  • Bioelectronic interfaces and devices
  • Electrophysiology in non-electrogenic cells
  • Signaling transduction in microbial communities
  • Novel biocompatible composite materials
  • Lab-on-a-chip devices for monitoring and modulating cells
  • Bioinformatics and machine learning applied to signal analysis
  • A tutorial complementing this symposium is tentatively planned.

Invited Speakers (tentative):

  • Paola Alberte (Instituto Superior Técnico, Portugal)
  • Daniel Chew (GlaxoSmithKline, United Kingdom)
  • Sonia Contera (University of Oxford, United Kingdom)
  • Leyla Esfandiari (University of Cincinnati, USA)
  • Paschalis Gkoupidenis (Max Planck Institute for Polymer Research, Germany)
  • Michael Levin (Tufts University, USA)
  • George Malliaras (Cambridge University, United Kingdom)
  • Ann Rajnicek (University of Aberdeen, United Kingdom)
  • Cynthia Reinhart-king (Vanderbilt University, USA)
  • Nuno Reis (University of Bath, United Kingdom)

Symposium Organizers

Paulo Rocha
University of Coimbra
Life Sciences
Portugal
No Phone for Symposium Organizer Provided , procha@uc.pt

Sina Jamali
University of New South Wales
School of Chemistry
Australia
No Phone for Symposium Organizer Provided , s.jamali@unsw.edu.au

Nathalia Peixoto
George Mason University
Bioengineering
USA
No Phone for Symposium Organizer Provided , npeixoto@gmu.edu

Frankie Rawson
The University of Nottingham
School of Pharmacy
United Kingdom
No Phone for Symposium Organizer Provided , Frankie.Rawson@nottingham.ac.uk

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MRS publishes with Springer Nature