11:45 AM - *SM09.02.01
β-Sheet Forming Peptide Hydrogels—From Self-Assembly to Functional Biomaterials
The University of Manchester1
The use of non-covalent self-assembly to construct materials has become a prominent strategy in biomaterials science offering practical routes for the construction of increasingly functional materials for a variety of applications ranging from cell culture and tissue engineering to in-vivo cell and drug delivery. A variety of molecular building blocks can be used for this purpose, one such block that has attracted considerable attention in the last 20 years is de-novo designed peptides. The β-sheet motif is of particular interest as short peptides can be designed to form β-sheet rich fibres that entangle and consequently form very stable hydrogels. These hydrogels can be easily functionalised using specific biological signals and can also be made responsive through the use of enzymatic catalysis [3-4] and/or conjugation with responsive polymers . Through the fundamental understanding of the self-assembly and gelation of these peptides across length scales [6-8] we have been able to design hydrogels with tailored properties for a range of applications including for the culture of a variety of cells[9-11], injectable and sprayable hydrogels for cell and drug delivery [12-13] as well as shear thinning hydrogel for 3D bio-printing [14-15]. The intrinsic biocompatibility  and low immunogenicity  of these materials makes them also ideal for TERM applications. Recently we have demonstrated their potential in a range of TERM applications including, oesophagus , nerve , intervertebral disk  and cardiac  regeneration.
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