The chemistry of membrane transport systems of interest for molecular information transfer has been extensively developed during the last twenty years. Our interest focus on hybrid solid membranes in which the molecular recognition-driven transport function could be ensured by a dynamic incorporation of specific organic receptors covalently and non-covalently linked in a dense and mesoporous siloxane inorganic matrix. Of particular interest is the potential ability of such solid membranes to combine functional properties such as solute molecular recognition, generation by self-assembling of the directional conduction pathways and target-constitutional evolution at the supramolecular level.From the mechanistic point of view, we use heteroditopic carriers which self-assemble in functional aggregates which would present combined (hybrid) intermediate features between the former carrier-monomers and the resulted pseudo-channel-forming superstructures. Thus, we therefore studied the membrane transport properties of such supramolecular systems resulted by the dynamic self-assembly of the hydrogen-bonded urea-crown ethers or bioorganic molecules in solid dense or mesoporous hybrid membranes. The crown-ether self-organized systems can be “frozen” in a polymeric hybrid matrix, opening the door to the design of a novel class of organic-inorganic nanomembranes. New self-organized hybrid membrane materials have been prepared from heteropolysiloxane superstructures chemically fixed in a silica matrix by sol-gel process. They have been employed to design the solid dense membranes, functioning as an ion-powered ATP pump.The selective recognition functions and self organization can be transferred inside regular mesoporous nanochannels. The MCM41-type mesostructured powders and membranes were used as hydrophobic or hydrophilic host matrix for physically or chemically entrapped 15-crown-5 and 18-crown-6 self-organized receptors. The combined features of structural adaptation in a specific hybrid nanospace and of dynamic supramolecular selection process make the membranes presented here of general interest for the development of a specific approach toward nanomembranes of increasing constitutional selectivity. 1.Barboiu, M.; Guizard, C.; Hovnanian, N.; Palmeri, J.; Reibel, C.; Luca, C.; Cot, L. J. Membrane Sci. 2000, 172, 91-103. 2.Barboiu, M.; Guizard, C.; Hovnanian, N.; Cot, L. Sep. Tech. Pur., 2001, 25, 211-218. 3.Barboiu, M.; Vaughan, G.; van der Lee A., Org. Lett., 2003, 5 (17), 3073-3076. 4.Barboiu, M., J. Incl. Phenom. Mol Rec. 2004, 49 133-137. 5.Barboiu, M.; Cerneaux, S.; Vaughan, G.; van der Lee, A.. J. Am. Chem. Soc., 2004, 126, 3545-3550. 6. Cazacu,A.; Tong,C.; van der Lee A., Fyles, T.; Barboiu,M. J. Am. Chem. Soc. 2006, 128, 9541-9548.