2:45 PM - EP03.02.04/EP02.02.04/EP04.02.04
Fully Implantable Wireless Battery-Free Optoelectronic Systems for Multimodal Optogenetic Neuromodulation
Philipp Gutruf1,Vaishnavi Krishnamurthi2,Abraham Vázquez-Guardado3,Zhaoqian Xie4,Anthony Banks5,Chun-Ju Su4,Yeshou Xu4,Chad Haney4,Emily Waters4,Irawati Kandela4,Siddharth Krishnan4,Tyler Ray4,John Leshock4,Yonggang Huang4,Debashis Chanda3,John Rogers4
University of Arizona1,RMIT University2,University of Central Florida3,Northwestern University4,Neurolux5
Show Abstract
Recently emerging classes of battery free, ultrasmall1, fully implantable devices for optogenetic neuromodulation2 eliminate physical tethers associated with bulky head-stages and batteries in alternative wireless technologies and conventional setups by leveraging cellular scale light emitting diodes on flexible injectable filaments as light sources3. These highly miniaturized systems enable untethered, operation for behavioral studies that eliminate motion constraints and enable new experimental paradigms in a range of complex 3D environments and contexts (e.g. social interactions) that cannot be explored with conventional technologies. These devices are, however, purely passive in their design, thereby precluding any form of active control or programmability, resulting in limitations when investigating circuit dynamics where independent operation of multiple light sources with precise active control is needed. Here we present a series of important concepts that enable controlled device operation, independent of position and angle relative to the experimental arena, with advanced wireless power harvesting capabilities and full user-programmability over multiple devices. This level of functionality is demonstrated in integrated platforms that are compatible with noninvasive imaging technologies such as computed tomography and magnetic resonance imaging and have sizes and weights not significantly larger than those of previous, passive systems. The resulting devices qualitatively expand options in brain tissue illumination for optogenetic neuromodulation and multimodal operation, with broad potential applications in neuroscience research, with specific advances in precise dissection of neural circuit function during unconstrained behavioral studies.
1 V. K. Samineni, J. Yoon, K. E. Crawford, Y. R. Jeong, K. C. McKenzie, G. Shin, Z. Xie, S. S. Sundaram, Y. Li, M. Y. Yang, J. Kim, D. Wu, Y. Xue, X. Feng, Y. Huang, A. D. Mickle, A. Banks, J. S. Ha, J. P. Golden, J. A. Rogers, and R. W. I. Gereau, PAIN 158,2017).
2 G. Shin, A. M. Gomez, R. Al-Hasani, Y. R. Jeong, J. Kim, Z. Q. Xie, A. Banks, S. M. Lee, S. Y. Han, C. J. Yoo, J. L. Lee, S. H. Lee, J. Kurniawan, J. Tureb, Z. Z. Guo, J. Yoon, S. I. Park, S. Y. Bang, Y. Nam, M. C. Walicki, V. K. Samineni, A. D. Mickle, K. Lee, S. Y. Heo, J. G. McCall, T. S. Pan, L. Wang, X. Feng, T. I. Kim, J. K. Kim, Y. H. Li, Y. G. Huang, R. W. Gereau, J. S. Ha, M. R. Bruchas, and J. A. Rogers, Neuron 93,2017).
3 T. I. Kim, J. G. McCall, Y. H. Jung, X. Huang, E. R. Siuda, Y. Li, J. Song, Y. M. Song, H. A. Pao, R. H. Kim, C. Lu, S. D. Lee, I. S. Song, G. Shin, R. Al-Hasani, S. Kim, M. P. Tan, Y. Huang, F. G. Omenetto, J. A. Rogers, and M. R. Bruchas, Science 340,2013).