9:00 PM - *SM04.05.01
Biomolecule-Based Nanostructures for Tumor Microenvironment Targeting and Regulation
National Center for Nanoscience and Technology1
It has witnessed that the rapid development on precision design and fabrication of intelligent next generation nanomedicines hold great potential to revolutionize the current landscape of drug development. It is also clear that tumor microenvironment plays critical roles on either promotion or restriction on primary tumor rapid growth and metastasis. Those achievements have made targeting and regulation of tumor microenvironment via responsive nanomedicines a feasible and fruitful strategy, to improve the therapeutic outcomes for cancer treatment. This presentation will feature our recent development on using biomolecule-based nanostructures as intelligent nanomedicines to regulate tumor microenvironment to block tumor microvessels or re-store the homeostasis of tumor stroma. Robotic molecular systems have great potential as intelligent vehicles to enable the delivery of various potent molecules, which otherwise never could be used as therapeutics due to numerous limitations. Yet, achieving in vivo, precise molecular-level, and on-demand targeting and delivery has proven extremely challenging. We developed nanorobotic systems for targeted cancer therapy, programmed to transport molecular payloads and cause on-site tumor infarction. Given the robust self-assembly behavior, exceptional designability, potent antitumor activity and minimal in vivo adversity, the development represents a promising strategy for precise drug design for cancer therapeutics.
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